Recombinant Mouse C-C motif chemokine 24 (Ccl24)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

Ccl24

Purity

>85% (SDS-PAGE)

Target Names

Ccl24

Uniprot NO.

Q9JKC0

Alternative Names

Ccl24; Scya24; C-C motif chemokine 24; Eosinophil chemotactic protein 2; Eotaxin-2; Small-inducible cytokine A24

Species

Mus musculus (Mouse)

Source

Yeast

Expression Region

27-119

Target Protein Sequence

VTIP SSCCTSFISK KIPENRVVSY QLANGSICPK AGVIFITKKG HKICTDPKLL WVQRHIQKLD AKKNQPSKGA KAVRTKFAVQ RRRGNSTEV
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.

Gene References into Functions

the increased airway eosinophils and mucous cell metaplasia in house dust mite-challenged Cd163-/- mice are mediated by augmented CCL24 production PMID:26376364
this study shows that TPL-2 inhibits Ccl24 expression in lung dendritic cells, and blockade of Ccl24 prevents the exaggerated airway eosinophilia and lung inflammation in mice given house dust mites-pulsed Map3k8-/- dendritic cells PMID:27484038
production in M-CSF-induced bone marrow-derived macrophages is synergistically induced by IL-4 and IL-10 PMID:25267883
Autologous transfer of peritoneal macrophages in to the airways of asthmatic mice reduces eotaxin production. PMID:24077949
Data indicate that eotaxin 2 (CCL-24), which is known to influence eosinophil migration, was highly up-regulated in broncho-alveolar macrophages (BAMs). PMID:23685352
The oesophageal production of CCL24 upon IL-13 stimulation is sufficient to promote eosinophil migration. PMID:20030665
Results demonstrate a cooperative mechanism between interleukin-13 and eotaxin-2, where IL-13 mediates allergen-induced eotaxin-2 expression, and eotaxin-2 mediates IL-13-induced airway eosinophilia. PMID:15647285
Distinct acidic and basic residues within CCR3 determine both receptor expression and activation by the eotaxins. PMID:16102831
The eotaxin-2 pathway plays a fundamental role in eosinophil recruitment during ovalbumin-induced experimental asthma. PMID:16210640
eosinophils via chemokine (C-C) receptor 3 have a central role in chronic allergic airway disease PMID:17060636
CCL24 seems important for recruitment of eosinophils into BAL. PMID:18850374