Recombinant Human Pancreatic adenocarcinoma up-regulated factor (ZG16B)

1. we conclude that the PAUF is a powerful and multifunctional promoter of tumor growth through increase and functional activation of myeloid-derived suppressor cells PMID:27322081
2. Mouse DCPP1 is a multifunctional promoter of tumor growth through functional activation of pancreatic cancer cells, suggesting it to be an ortholog of human PAUF. PMID:28988106
3. Our results suggest that PAUF has tumour-promoting functions in oral squamous cell carcinoma PMID:27706833
4. High PAUF expression is associated with resistance to gemcitabine in pancreatic cancer. PMID:26684804
5. PAUF mediated dendritic cell activation and immune stimulation are dependent on TLR4 PMID:26336989
6. constitutive suppression of PAUF sensitized Bxpc3 pancreatic cancer cells to oncolytic parvovirus H-1 infection PMID:25727013
7. PAUF rs12373A>C polymorphisms are associated with colorectal cancer. PMID:25079514
8. PAUF-siRNA inhibited the proliferation of colorectal cancer cells, promoted their apoptosis and induced G0/G1 cell cycle arrest. At the same time, PAUF-siRNA inhibited the invasion, adhesion and migration of the tumor cells. PMID:23677445
9. new possibilities for PAUF's role in the pathogenesis of angiogenesis-dependent diseases PMID:22907431
10. activation of SIRT1 inhibited the proliferation of pancreatic cancer -PAUF cells by down-regulation of cyclin-D1, a target molecule of beta-catenin. PMID:22640743
11. PAUF-mediated FAK activation plays an important role in pancreatic cancer progression. PMID:21464589
12. PAUF can up-regulate and stabilize beta-catenin via a novel pattern of phosphorylation, thereby contributing to the rapid proliferation of pancreatic cancer cells. PMID:21196815
13. Data demonstrate that the host salivary protein CSP-1 (HRPE773 GenBank AAQ89380.1) binds to S. mutans cells and may influence the initial colonization of this pathogenic bacterium onto the tooth surface. PMID:20858015
14. the sugar-binding site and the adjacent basic patch of ZG16p and ZG16b cooperatively form a functional glycosaminoglycan-binding site. PMID:21110947
15. PAUF is a mammalian lectin normally found in plant lectins. PAUF induces extracellular signal-regulated kinase phosphorylation and activates the IKK-b-mediated TPL2/MEK/ERK signaling pathway through TLR2. PMID:20802527
16. Findings indicate that PAUF enhances the metastatic potential of pancreatic cancer cells, at least in part, by upregulating CXCR4 expression. PMID:19784070
17. Bioinformatic analysis identified a putative human CSP-1/Dcpp ortholog, HRPE773, expressed predominantly in human salivary tissue, that shows 31% amino acid identity and 45% amino acid similarity to the mouse Dcpp query sequence. PMID:16954406
18. pancreatic adenocarcinoma up-regulated factor was secreted into the culture medium of pancreatic adenocarcinoma up-regulated factor-overexpressing Chinese hamster ovary cells, had an apparent molecular mass of approximately 25 kDa, and was N-glycosylated PMID:19302292

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HGNC: 30456

UNIGENE: Hs.105887

KEGG: hsa:124220

STRING: 9606.ENSP00000371715