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Recombinant Human Vesicle-associated membrane protein-associated protein A (VAPA), partial

Recombinant Human Vesicle-associated membrane protein-associated protein A (VAPA), partial

Baculovirus
Mammalian cell

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

VAPA

Purity

>85% (SDS-PAGE)

Target Names

VAPA

Uniprot NO.

Q9P0L0

Alternative Names

33 kDa Vamp-associated protein; hVAP 33; MGC3745; OTTHUMP00000162362; OTTHUMP00000162363; VAMP (vesicle-associated membrane protein) associated protein A, 33kDa; VAMP A; VAMP associated protein A; VAMP-A; VAMP-associated protein A; VAP 33; VAP A; VAP-33; VAP-A; VAP33; Vapa; VAPA_HUMAN; Vesicle associated membrane protein associated protein A; Vesicle-associated membrane protein-associated protein A

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.

Gene References into Functions

The effects of sterol manipulation of HuH7 cells on complexes of established sterol-binding Oxysterol-binding protein related proteins with their endoplasmic reticulum receptor, VAMP-associated protein A (VAPA), were examined. PMID:25681634
phosphorylation of ORP3 controls its association with VAPA. Furthermore, ORP3-VAPA complexes stimulate R-Ras signaling. PMID:25447204
GPS2 is required for the association of viral NS5A with VAP-A and hepatitis C virus replication. PMID:24223774
STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the endoplasmic reticulum. PMID:24105263
phosphorylation of CERT at the FFAT motif-adjacent serine affects its affinity for VAP, which may regulate the inter-organelle trafficking of ceramide in response to the perturbation of cellular sphingomyelin and/or other sphingolipids PMID:24569996
Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein VAP-33. PMID:21957124
Data show that the methylated VAPA-APCDD1 DNA in maternal plasma is predominantly derived from the fetus, and this novel fetal epigenetic marker in maternal plasma is useful for the noninvasive detection of fetal trisomy 18. PMID:21152411
Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies. PMID:20178991
protein-protein interactions among the various HCV NS proteins and hVAP-33 are important for the formation of HCV replication complex PMID:15016871
Our results provide suggestive evidence of an association between SNPs in the 3'UTR of the VAPA gene and bipolar disorder. PMID:18665321
VAP-A is an important regulator both of the subcellular localization of protrudin and of its ability to stimulate neurite outgrowth. PMID:19289470
GLTP and VAP-A were shown to interact. PMID:19665998

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Subcellular Location

Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass type IV membrane protein. Cell junction, tight junction. Nucleus membrane.

Protein Families

VAMP-associated protein (VAP) (TC 9.B.17) family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 12648

UNIGENE: Hs.165195

KEGG: hsa:9218

OMIM: 605703

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