VAPA Antibody

Code: CSB-PA025789GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: ELISA,WB,IHC

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Target Background

Product Details

Uniprot NO.

Q9P0L0

Target Names

VAPA

Alternative Names

33 kDa Vamp-associated protein antibody; hVAP 33 antibody; MGC3745 antibody; OTTHUMP00000162362 antibody; OTTHUMP00000162363 antibody; VAMP (vesicle-associated membrane protein) associated protein A, 33kDa antibody; VAMP A antibody; VAMP associated protein A antibody; VAMP-A antibody; VAMP-associated protein A antibody; VAP 33 antibody; VAP A antibody; VAP-33 antibody; VAP-A antibody; VAP33 antibody; Vapa antibody; VAPA_HUMAN antibody; Vesicle associated membrane protein associated protein A antibody; Vesicle-associated membrane protein-associated protein A antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Human VAPA

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Binds to OSBPL3, which mediates recruitment of VAPA to plasma membrane sites. The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.

Gene References into Functions

The effects of sterol manipulation of HuH7 cells on complexes of established sterol-binding Oxysterol-binding protein related proteins with their endoplasmic reticulum receptor, VAMP-associated protein A (VAPA), were examined. PMID:25681634
phosphorylation of ORP3 controls its association with VAPA. Furthermore, ORP3-VAPA complexes stimulate R-Ras signaling. PMID:25447204
GPS2 is required for the association of viral NS5A with VAP-A and hepatitis C virus replication. PMID:24223774
STARD3 or STARD3NL and VAP form a novel molecular tether between late endosomes and the endoplasmic reticulum. PMID:24105263
phosphorylation of CERT at the FFAT motif-adjacent serine affects its affinity for VAP, which may regulate the inter-organelle trafficking of ceramide in response to the perturbation of cellular sphingomyelin and/or other sphingolipids PMID:24569996
Viperin inhibits hepatitis C virus replication by interfering with binding of NS5A to host protein VAP-33. PMID:21957124
Data show that the methylated VAPA-APCDD1 DNA in maternal plasma is predominantly derived from the fetus, and this novel fetal epigenetic marker in maternal plasma is useful for the noninvasive detection of fetal trisomy 18. PMID:21152411
Electrostatic interaction between oxysterol-binding protein and VAMP-associated protein A revealed by NMR and mutagenesis studies. PMID:20178991
protein-protein interactions among the various HCV NS proteins and hVAP-33 are important for the formation of HCV replication complex PMID:15016871
Our results provide suggestive evidence of an association between SNPs in the 3'UTR of the VAPA gene and bipolar disorder. PMID:18665321
VAP-A is an important regulator both of the subcellular localization of protrudin and of its ability to stimulate neurite outgrowth. PMID:19289470
GLTP and VAP-A were shown to interact. PMID:19665998

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Subcellular Location

Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Cell membrane; Single-pass type IV membrane protein. Cell junction, tight junction. Nucleus membrane.

Protein Families

VAMP-associated protein (VAP) (TC 9.B.17) family

Tissue Specificity

Ubiquitous.

Database Links

HGNC: 12648

UNIGENE: Hs.165195

KEGG: hsa:9218

OMIM: 605703

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