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Recombinant Human Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2), partial

Recombinant Human Transmembrane and immunoglobulin domain-containing protein 2 (TMIGD2), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

TMIGD2

Purity

>85% (SDS-PAGE)

Target Names

TMIGD2

Uniprot NO.

Q96BF3

Alternative Names

Transmembrane and immunoglobulin domain-containing protein 2; CD28 homolog; Immunoglobulin and proline-rich receptor 1 (IGPR-1); TMIGD2; CD28H, IGPR1; UNQ3059/PRO9879

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Buffer

Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

Gene References into Functions

The authors demonstrate that IGPR-1 is localized to endothelial adherens junctions and, through trans-homophilic dimerization, regulates endothelial cell-cell adhesion and barrier function. PMID:27838321
B7 homologue 5 (B7-H5), was identified as a specific ligand for CD28H. PMID:23784006
Authors identified IGPR-1, also called TMIGD2, gene as a novel cell adhesion receptor that is expressed in various human organs and tissues, mainly in cells with epithelium and endothelium origins. PMID:22419821

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands

Database Links

HGNC: 28324

UNIGENE: Hs.263928

KEGG: hsa:126259

OMIM: 614715

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