TMIGD2 Antibody, FITC conjugated

Code: CSB-PA850263LC01HU

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50μg100μg

US$166

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Species Reactivity: Human

Raised in: Rabbit

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Target Background

Product Details

Uniprot NO.

Q96BF3

Target Names

TMIGD2

Alternative Names

CD28H antibody; IGPR 1 antibody; IGPR1 antibody; immunoglobulin and proline-rich receptor 1 antibody; immunoglobulin-containing and proline-rich receptor 1 antibody; TMIG2_HUMAN antibody; TMIGD2 antibody; Transmembrane and immunoglobulin domain containing 2 antibody; Transmembrane and immunoglobulin domain-containing protein 2 antibody; transmembrane and immunoglobulin domain-containing protein 2 variant 2 antibody; transmembrane and immunoglobulin domain-containing protein 2 variant 3 antibody; UNQ3059/PRO9879 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Transmembrane and immunoglobulin domain-containing protein 2 protein (23-150AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.

Gene References into Functions

The authors demonstrate that IGPR-1 is localized to endothelial adherens junctions and, through trans-homophilic dimerization, regulates endothelial cell-cell adhesion and barrier function. PMID:27838321
B7 homologue 5 (B7-H5), was identified as a specific ligand for CD28H. PMID:23784006
Authors identified IGPR-1, also called TMIGD2, gene as a novel cell adhesion receptor that is expressed in various human organs and tissues, mainly in cells with epithelium and endothelium origins. PMID:22419821

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Subcellular Location

Cell membrane; Single-pass type I membrane protein.

Tissue Specificity

Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum, endometrial glands

Database Links

HGNC: 28324

UNIGENE: Hs.263928

KEGG: hsa:126259

OMIM: 614715

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