Recombinant Human P2Y purinoceptor 11 (P2RY11), partial

1. these results show hepatocellular carcinoma-specific expression of the P2Y11 receptor and its critical role in mediating ATP-inducing Ca2+ signalling and regulating cancer cell migration PMID:28418839
2. Decreased P2Y11 signaling plays an important role in the development of narcolepsy with cataplexy. PMID:28460015
3. Hypoxia/reoxygenation inhibits P2y11 receptor expression and its immunosuppressive activity in human dendritic cells. PMID:26078273
4. Suggest role for LXA4 in stimulating apical ATP secretion via pannexin-1 channels and P2RY11 purinoreceptors activation leading to an airway surface liquid layer height increase and epithelial repair. PMID:24588705
5. vesicular exocytosis of ATP and autocrine, positive feedback through P2Y11 receptors is required for the effective activation of macrophages PMID:23577075
6. P2Y11 receptor mediates interferon gamma-induced IL-6 production in HaCaT cells, suggesting the importance of purinergic signaling in interferon-gamma induced skin inflammatory conditions PMID:23461851
7. P2Y11 receptors are abundantly and diffusely expressed intracellularly in skeletal muscle fibers. PMID:22052557
8. The study extends on the observation of a strong multiethnic association of polymorphisms in the TCRA and P2RY11 with narcolepsy, but does not confirm the association of CPT1B/CHKB (rs5770917) in the Chinese population. PMID:22177342
9. Extracellular NAD stimulates mesenchymal stem cell functions through activation of P2Y11 receptor. PMID:20964598
10. Common variants in P2RY11 are associated with narcolepsy. PMID:21170044
11. Inhibition of Natural killer cell response to CX3CL1 is mediated by the P2Y11 receptor. PMID:20668227
12. beta-NAD(e)+ is an agonist of the P2Y(11) purinoceptor and P2Y(11) is the endogenous receptor in granulocytes mediating the sustained [Ca2+]i increase responsible for their functional activatio PMID:16926152
13. We propose that residues Arg106, Arg268, Arg307 and Glu186 are involved in ionic interactions with the phosphate moiety of ATP. Arg307 is possibly also H-bonded to N6 of ATP via the backbone carbonyl. PMID:17338680
14. In human granulocytes, endogenous P2Y(11) proved to be responsible for NAADP+-induced cell activation, unveiling a role of NAADP+ as a pro-inflammatory cytokine. PMID:17707504
15. The P2 receptor mediating the antiapoptotic actions of ATP was identified using a combination of more selective ATP analogs, receptor expression studies, and study of downstream signaling pathways. PMID:18056402
16. present data clearly show that P2Y purinoceptor 11 and P2Y purinoceptor 12 are expressed in human pancreatic islets PMID:18726826

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HGNC: 8540

UNIGENE: Hs.14468

KEGG: hsa:5032

STRING: 9606.ENSP00000323872

OMIM: 602697