Recombinant Human NLR family CARD domain-containing protein 4 (NLRC4), partial

1. Study findings suggest that NLRC4 may be involved in the exacerbation or modification of psoriatic lesions. PMID:29797527
2. Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1 PMID:30279182
3. obesity-associated NLRC4 inflammasome activation/ interleukin-1 signalling promotes breast cancer progression in humans and in mouse models PMID:27708283
4. this study shows that human NAIP-NLRC4-inflammasome senses the Pseudomonas aeruginosa T3SS inner-rod protein PMID:28992059
5. mRNA expression levels of NLRP1 and NLRC4 were not altered in chronic hepatitis B patients, suggesting that these genes are not responsible for the impaired immune responses against HBV observed in these patients. PMID:27750030
6. The authors describe a novel mutation in NLRC4 in a large pedigree causing an NLRC4-associated, partially anakinra-responsive AID, dominated by cutaneous erythematous nodes and urticarial rash, arthralgias, and late-onset enterocolitis. PMID:27203668
7. Results found that NLRC4 expression increased in for promoting DN progression and demonstrate NLRC4-driven IL-1beta production as critical for the progression of DN. PMID:27706238
8. Ubiquitin-tagged NLRC4 could induce cell death and activate caspase-8 independent of Ser(533) phosphorylation. Our PMID:27974463
9. LPS activates the MAPK pathway in macrophages, thus resulting in the upregulation of NLRC4; however, NLRC4 inhibits IL1beta and IL18 production, contributing to the anti-inflammatory response. PMID:27175981
10. High expression of NLRP3, NLRC4, and CASP1 in background non-tumorous liver is significantly correlated with poor prognosis of patients after resection of hepatocellular carcinoma. PMID:28011505
11. association of IL-18 levels with a single nucleotide polymorphism in the untranslated exon 2 of the inflammasome component NLRC4 PMID:26362438
12. While both contributing to pathogen clearance, NLRP3 more than NLRC4 contributes to deleterious inflammatory responses in cystic fibrosis and correlates with defective NLRC4-dependent IL-1Ra production. PMID:26972847
13. analysis of a subset of inflammasome receptors including NLRP3, NLRC4 and AIM2 that triggers formation of the micrometer-sized spherical supramolecular complex called the ASC speck PMID:26258904
14. Thus, pathogenic inflammasome activity during Candida infection is negatively regulated by the IL-22/NLRC4/IL-1Ra axis. PMID:26269955
15. cN-II co-immunoprecipitated both with wild type Ipaf and its LRR domain after transfection with corresponding expression vectors, but not with Ipaf lacking the LRR domain. PMID:25811392
16. Elevated expression of IPAF was associated with inflammation in patients with pemphigus vulgaris disease. PMID:25342284
17. Data indicate that NLR family CARD domain containing 4 protein (NLRC4) is a causative gene for familial cold autoinflammatory syndrome (FCAS). PMID:25385754
18. Data show that the disease was caused by a de novo gain-of-function mutation in NLR family CARD domain containing 4 (NLRC4) encoding a p.Val341Ala substitution. PMID:25217960
19. inflammasome (also known as NLRC4) has been demonstrated to play a role in host defense mechanisms against pathogen-associated molecules PMID:24054992
20. This review describes the surprisingly diverse mechanisms by which NLRC4 senses bacteria and initiates innate immune responses. PMID:23215645
21. the NAIP5-NLRC4 inflammasome is induced by direct interactions with conserved N- and C-terminal regions of flagellin PMID:23012363
22. NLRC4 is important for host survival and bacterial clearance, as well as neutrophil-mediated inflammation in the lungs following Klebsiella pneumoniae infection. PMID:22547706
23. Twelve single nucleotide polymorphisms within NLRP1, NLRP3, NLRC4, CARD8, CASP1, and IL1B genes were analyzed in 150 HIV-1-infected Brazilian subjects. PMID:22227487
24. Genetic analysis of Chromobacterium violaceum infection revealed that the TTSS needle protein CprI can stimulate NLRC4 inflammasome activation in human macrophages PMID:21918512
25. [review] role of NLRC4 inflammasome and pathways in innate immune detection of bacterial virulence factors PMID:20349122
26. Apaf-1 protein expression did not correlate with Apaf-1 mRNA levels in human leukaemic blasts.Apaf-1 DNA promoter methylation might contribute to the inactivation of Apaf-1 expression PMID:12545166
27. CLAN regulates several events central to host defense mechanisms against invading bacteria: modulating relative sensitivity of macrophages to lipopolysaccharide and peptidoglycan, and impacting host-pathogen interactions. PMID:15528373
28. p53 can directly induce Ipaf gene transcription, which contributes to p53-dependent apoptosis in at least some human cells PMID:15580302
29. Involvement of caspase 1 and its activator Ipaf upstream of mitochondrial events in apoptosis PMID:16817903
30. hNAIP and hIpaf mediate innate intracellular defense against flagellated Legionella in human cells. PMID:18453601

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HGNC: 16412

UNIGENE: Hs.574741

KEGG: hsa:58484

STRING: 9606.ENSP00000354159

OMIM: 606831