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Recombinant Human Matrix extracellular phosphoglycoprotein (MEPE)

Recombinant Human Matrix extracellular phosphoglycoprotein (MEPE)

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MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

MEPE

Purity

>85% (SDS-PAGE)

Target Names

MEPE

Uniprot NO.

Q9NQ76

Alternative Names

Matrix extracellular phosphoglycoprotein; MEPE; MEPE_HUMAN; OF45; Osteoblast/osteocyte factor 45

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

18-525

Target Protein Sequence

PTF QPQTEKTKQS CVEEQRQEEK NKDNIGFHHL GKRINQELSS KENIVQERKK DLSLSEASEN KGSSKSQNYF TNRQRLNKEY SISNKENTHN GLRMSIYPKS TGNKGFEDGD DAISKLHDQE EYGAALIRNN MQHIMGPVTA IKLLGEENKE NTPRNVLNII PASMNYAKAH SKDKKKPQRD SQAQKSPVKS KSTHRIQHNI DYLKHLSKVK KIPSDFEGSG YTDLQERGDN DISPFSGDGQ PFKDIPGKGE ATGPDLEGKD IQTGFAGPSE AESTHLDTKK PGYNEIPERE ENGGNTIGTR DETAKEADAV DVSLVEGSND IMGSTNFKEL PGREGNRVDA GSQNAHQGKV EFHYPPAPSK EKRKEGSSDA AESTNYNEIP KNGKGSTRKG VDHSNRNQAT LNEKQRFPSK GKSQGLPIPS RGLDNEIKNE MDSFNGPSHE NIITHGRKYH YVPHRQNNST RNKGMPQGKG SWGRQPHSNR RFSSRRRDDS SESSDSGSSS ESDGD
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Promotes renal phosphate excretion and inhibits intestinal phosphate absorption. Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage. Promotes dental pulp stem cell proliferation and differentiation.

Gene References into Functions

Results indicate an association of MEPE gene inactivation with decreased survival after DNA damage. PMID:23570370
Mice deficient in an ortholog of MEPE show increased bone mass and are resistant to aging-related bone loss. PMID:12421822
results indicated that MEPE appeared to play an important positive role in proliferation and osteogenesis differentiation of DPCs through interaction with downstream signals. PMID:22341070
MEPE or the MEPE-derived acidic serine aspartate-rich MEPE-associated motif peptide may contribute to decreased bone mineralization in Oncogenic osteomalacia patients. PMID:21739089
Among migraineurs with aura rs7698623 in MEPE (OR = 6.37; 95% CI 3.15-12.90; p = 2.7x10(-7)) and rs4975709 in IRX4 (OR = 5.06; 95% CI 2.66-9.62; p = 7.7x10(-7)) appeared to be associated with ischemic stroke. PMID:21779381
Sclerostin acts through regulation of the PHEX/MEPE axis at the preosteocyte stage and serves as a master regulator of physiologic bone mineralization. PMID:21312267
MEPE may play a regulatory role in periodontal ligament cell osteogenic differentiation. PMID:19031789
These results suggest that abnormal MEPE cleavage occurs when PHEX activity is deficient in humans. PMID:20581062
This study demonstrates the importance of posttranslational modification for the site-specific activity of MEPE and its ASARM peptide. PMID:19998030
The patterns of expression of FGF-23, MEPE, and DMP1 differ markedly in trabecular bone, suggesting that individual osteocytes may have specialized functions. PMID:19679205
MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21. Expressed during odontogenesis. PMID:12489176
There is evidence for a hormone/enzyme/extracellular matrix protein cascade involving fibroblastic growth factor 23 (FGF23), a phosphate-regulating gene with homologies to (PHEX) and (MEPE)--REVIEW PMID:12791601
MEPE is predominantly expressed by osteocytes in human bone, with significant expression by osteocytes within mineralized bone PMID:15108058
The results are consistent with MEPE being involved in phosphate and bone metabolism in a normal population. PMID:15292364
MEPE expression is higher when cells proliferate, whereas it is downregulated as cells differentiated PMID:18547474
MEPE is a candidate phosphatonin involved in phosphate homeostasis, acting in both the kidney and the gastrointestinal tract PMID:19005008
MEPE is expressed in salivary gland ducts. PMID:15329369
MEPE is expressed on the luminal surface of kidney proximal tubules. PMID:15954904

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Subcellular Location

Secreted, extracellular space, extracellular matrix.

Tissue Specificity

Expressed by osteoblasts. Expressed by stem cells in dental pulp. Expressed by mesenchymal cells in dental papilla and dental pulp. Expressed in teeth, specifically in decidious dentin. Expressed in ondotoblasts. Expressed in salivary glands. Secreted fro

Database Links

HGNC: 13361

UNIGENE: Hs.676357

KEGG: hsa:56955

STRING: 9606.ENSP00000354341

OMIM: 605912

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