MEPE Antibody

Code: CSB-PA013704GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: ELISA,WB

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Target Background

Product Details

Uniprot NO.

Q9NQ76

Target Names

MEPE

Alternative Names

Matrix extracellular phosphoglycoprotein antibody; MEPE antibody; MEPE_HUMAN antibody; OF45 antibody; Osteoblast/osteocyte factor 45 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Human MEPE

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Protocols

ELISA Protocol Western Blotting(WB) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Promotes renal phosphate excretion and inhibits intestinal phosphate absorption. Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes. Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage. Promotes dental pulp stem cell proliferation and differentiation.

Gene References into Functions

Results indicate an association of MEPE gene inactivation with decreased survival after DNA damage. PMID:23570370
Mice deficient in an ortholog of MEPE show increased bone mass and are resistant to aging-related bone loss. PMID:12421822
results indicated that MEPE appeared to play an important positive role in proliferation and osteogenesis differentiation of DPCs through interaction with downstream signals. PMID:22341070
MEPE or the MEPE-derived acidic serine aspartate-rich MEPE-associated motif peptide may contribute to decreased bone mineralization in Oncogenic osteomalacia patients. PMID:21739089
Among migraineurs with aura rs7698623 in MEPE (OR = 6.37; 95% CI 3.15-12.90; p = 2.7x10(-7)) and rs4975709 in IRX4 (OR = 5.06; 95% CI 2.66-9.62; p = 7.7x10(-7)) appeared to be associated with ischemic stroke. PMID:21779381
Sclerostin acts through regulation of the PHEX/MEPE axis at the preosteocyte stage and serves as a master regulator of physiologic bone mineralization. PMID:21312267
MEPE may play a regulatory role in periodontal ligament cell osteogenic differentiation. PMID:19031789
These results suggest that abnormal MEPE cleavage occurs when PHEX activity is deficient in humans. PMID:20581062
This study demonstrates the importance of posttranslational modification for the site-specific activity of MEPE and its ASARM peptide. PMID:19998030
The patterns of expression of FGF-23, MEPE, and DMP1 differ markedly in trabecular bone, suggesting that individual osteocytes may have specialized functions. PMID:19679205
MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21. Expressed during odontogenesis. PMID:12489176
There is evidence for a hormone/enzyme/extracellular matrix protein cascade involving fibroblastic growth factor 23 (FGF23), a phosphate-regulating gene with homologies to (PHEX) and (MEPE)--REVIEW PMID:12791601
MEPE is predominantly expressed by osteocytes in human bone, with significant expression by osteocytes within mineralized bone PMID:15108058
The results are consistent with MEPE being involved in phosphate and bone metabolism in a normal population. PMID:15292364
MEPE expression is higher when cells proliferate, whereas it is downregulated as cells differentiated PMID:18547474
MEPE is a candidate phosphatonin involved in phosphate homeostasis, acting in both the kidney and the gastrointestinal tract PMID:19005008
MEPE is expressed in salivary gland ducts. PMID:15329369
MEPE is expressed on the luminal surface of kidney proximal tubules. PMID:15954904

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Subcellular Location

Secreted, extracellular space, extracellular matrix.

Tissue Specificity

Expressed by osteoblasts. Expressed by stem cells in dental pulp. Expressed by mesenchymal cells in dental papilla and dental pulp. Expressed in teeth, specifically in decidious dentin. Expressed in ondotoblasts. Expressed in salivary glands. Secreted fro

Database Links

HGNC: 13361

UNIGENE: Hs.676357

KEGG: hsa:56955

STRING: 9606.ENSP00000354341

OMIM: 605912

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