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Recombinant Human Killer cell lectin-like receptor subfamily F member 1 (KLRF1), partial

Recombinant Human Killer cell lectin-like receptor subfamily F member 1 (KLRF1), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

KLRF1

Purity

>85% (SDS-PAGE)

Target Names

KLRF1

Uniprot NO.

Q9NZS2

Alternative Names

KLRF1; CLEC5C; MLKiller cell lectin-like receptor subfamily F member 1; Lectin-like receptor F1; Activating coreceptor NKp80; C-type lectin domain family 5 member C

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.

Gene References into Functions

NKp80 is a marker of natural killer (NK) cell maturity in secondary lymphoid tissues and supports NK cell development through a stage 4a intermediate with ILC3-associated features. PMID:27373165
Two non-consensus amino acids of NKp80, in particular arginine 6, critically impair both hemi-immunoreceptor tyrosine-based activation motif phosphorylation and Syk recruitment. PMID:23609447
Activating receptor NKp80 induces cytotoxicity by using an atypical hemi-ITAM amino acid seqeuence and the Syk-kinase pathway. PMID:21149606

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Subcellular Location

Membrane; Single-pass type II membrane protein.

Tissue Specificity

Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart, placenta, lung, kidney, skeletal muscle,

Database Links

HGNC: 13342

UNIGENE: Hs.183125

KEGG: hsa:51348

STRING: 9606.ENSP00000279544

OMIM: 605029

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