KLRF1 Antibody

Code: CSB-PA192826

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Size:

50μl100μl

US$166

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: ELISA,WB,IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

Q9NZS2

Target Names

KLRF1

Alternative Names

KLRF1 antibody; CLEC5C antibody; MLKiller cell lectin-like receptor subfamily F member 1 antibody; Lectin-like receptor F1 antibody; Activating coreceptor NKp80 antibody; C-type lectin domain family 5 member C antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide of Human KLRF1

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA,WB,IHC

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA192826(KLRF1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA192826(KLRF1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane: Human bladder carcinoma tissue, Primary antibody: CSB-PA192826(KLRF1 Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes

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Target Background

Function(From Uniprot)

Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.

Gene References into Functions

NKp80 is a marker of natural killer (NK) cell maturity in secondary lymphoid tissues and supports NK cell development through a stage 4a intermediate with ILC3-associated features. PMID:27373165
Two non-consensus amino acids of NKp80, in particular arginine 6, critically impair both hemi-immunoreceptor tyrosine-based activation motif phosphorylation and Syk recruitment. PMID:23609447
Activating receptor NKp80 induces cytotoxicity by using an atypical hemi-ITAM amino acid seqeuence and the Syk-kinase pathway. PMID:21149606

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Subcellular Location

Membrane; Single-pass type II membrane protein.

Tissue Specificity

Strongly expressed in peripheral blood leukocytes and spleen, with weaker expression in lymph node and adult liver, and no expression detected in bone marrow, thymus, and fetal liver. Not expressed in brain, heart, placenta, lung, kidney, skeletal muscle,

Database Links

HGNC: 13342

UNIGENE: Hs.183125

KEGG: hsa:51348

STRING: 9606.ENSP00000279544

OMIM: 605029

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