Home
Product
Protein
Recombinant Proteins
Recombinant Human Interleukin-27 receptor subunit alpha (IL27RA), partial

Recombinant Human Interleukin-27 receptor subunit alpha (IL27RA), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
Have Questions?	Leave a Message or Start an on-line Chat

Product Details
Related Products
Customer Reviews and Q&A
Target Background

Product Details

Abbreviation

IL27RA

Purity

>85% (SDS-PAGE)

Target Names

IL27RA

Uniprot NO.

Q6UWB1

Alternative Names

Class I cytokine receptor; CRL1; Cytokine receptor-like 1; I27RA_HUMAN; IL-27 receptor subunit alpha; IL-27R subunit alpha; IL-27R-alpha; IL-27RA; IL27R alpha; IL27R; Il27ra; Interleukin 27 receptor alpha chain precursor; Interleukin 27 receptor; Interleukin-27 receptor subunit alpha; Protein CRL1; T cell cytokine receptor type 1; TCCR; Type 1 T cell cytokine receptor; Type I T-cell cytokine receptor; WSX-1; WSX1; ZcytoR1

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

■ Customer Reviews

Submit a Review here

Target Background

Function(From Uniprot)

Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.

Gene References into Functions

this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1) on fetal membranes in cases of preterm birth PMID:28756371
These results identify IL-27 and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection. PMID:28592538
Findings demonstrated that IL-27 and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 can modulate immune properties of astrocytes and infiltrating immune cells PMID:26649511
The significant expression of IL-27 in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor pair is detrimental in TB. PMID:26282876
natural sIL-27Ralpha binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a potent inhibitor of IL-27 signaling, as shown by its ability to specifically block IL-27-mediated STAT activation, at low molar excess over IL-27. PMID:24771852
Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes. PMID:22936014
TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with age-related macular degeneration. PMID:22312192
Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity. PMID:21631431
WSX-1 is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation. PMID:12734330
WSX-1 together with the cytokine receptor gp130 constitutes a functional signal-transducing receptor for IL-27. PMID:14764690
IL-27R possesses hematopoietic cell-transforming properties PMID:18003935
These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130. PMID:19386761
Results reveal an interleukin 27-independent function of WSX1 sensitizing natural killer cell-mediated antitumor surveillance. PMID:19549909

Hide All

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Type I cytokine receptor family, Type 2 subfamily

Tissue Specificity

Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, s

Database Links

HGNC: 17290

UNIGENE: Hs.132781

KEGG: hsa:9466

STRING: 9606.ENSP00000263379

OMIM: 605350

Promotions