IL27RA Antibody

Code: CSB-PA761488ESR1HU

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20μl50μl100μl

US$83

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Species Reactivity: Human, Rat

Raised in: Rabbit

Application: ELISA, WB, IHC

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Target Background

Product Details

Uniprot NO.

Q6UWB1

Target Names

IL27RA

Alternative Names

Class I cytokine receptor antibody; CRL1 antibody; Cytokine receptor-like 1 antibody; I27RA_HUMAN antibody; IL-27 receptor subunit alpha antibody; IL-27R subunit alpha antibody; IL-27R-alpha antibody; IL-27RA antibody; IL27R alpha antibody; IL27R antibody; Il27ra antibody; Interleukin 27 receptor alpha chain precursor antibody; Interleukin 27 receptor antibody; Interleukin-27 receptor subunit alpha antibody; Protein CRL1 antibody; T cell cytokine receptor type 1 antibody; TCCR antibody; Type 1 T cell cytokine receptor antibody; Type I T-cell cytokine receptor antibody; WSX-1 antibody; WSX1 antibody; ZcytoR1 antibody

Raised in

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant Human Interleukin-27 receptor subunit alpha protein (33-283AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:2000
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: IL27RA antibody at 9μg/ml
Lane 1: Rat heart tissue
Lane 2: Rat brain tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 69 kDa
Observed band size: 69 kDa
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA761488ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA761488ESR1HU at dilution of 1:100

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Citations

A Target Discovery Pipeline Identified ILT3 as a Target for Immunotherapy of Multiple Myeloma F Di Meo,/,2023

Target Background

Function(From Uniprot)

Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR. Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.

Gene References into Functions

this study found elevated expression of IL-27 in human peripheral serum and elevated expression of its specific receptor (wsx-1) on fetal membranes in cases of preterm birth PMID:28756371
These results identify IL-27 and its specific receptor IL27RA as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection. PMID:28592538
Findings demonstrated that IL-27 and IL-27R were elevated in multiple sclerosis lesions and that local IL-27 can modulate immune properties of astrocytes and infiltrating immune cells PMID:26649511
The significant expression of IL-27 in TB and the negative influence of IL-27R on T cell function demonstrate the pathway by which this cytokine/receptor pair is detrimental in TB. PMID:26282876
natural sIL-27Ralpha binds rIL-27, inhibits IL-27 binding to its cell surface receptor, and is a potent inhibitor of IL-27 signaling, as shown by its ability to specifically block IL-27-mediated STAT activation, at low molar excess over IL-27. PMID:24771852
Aberrant hypermethylation and reduced expression of IL27RA is associated with myelodysplastic syndromes. PMID:22936014
TCCR/WSX-1 is closely associated with angiogenesis and could serve as a novel therapeutic target in patients with age-related macular degeneration. PMID:22312192
Mutations in the transmembrane and juxtamembrane domains enhance IL27R transforming activity. PMID:21631431
WSX-1 is essential for transcriptional activation of STAT1 and for augmenting the induction of T-bet expression during initiation of Th1 cell differentiation. PMID:12734330
WSX-1 together with the cytokine receptor gp130 constitutes a functional signal-transducing receptor for IL-27. PMID:14764690
IL-27R possesses hematopoietic cell-transforming properties PMID:18003935
These results indicate that humanin protects neurons by binding to a complex or complexes involving CNTFR/WSX-1/gp130. PMID:19386761
Results reveal an interleukin 27-independent function of WSX1 sensitizing natural killer cell-mediated antitumor surveillance. PMID:19549909

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Type I cytokine receptor family, Type 2 subfamily

Tissue Specificity

Highly expressed in lymphoid tissues such as spleen, lymph nodes and peripheral blood leukocytes. Weakly expressed in other tissues examined including heart, brain, fetal and adult lung, liver, skeletal muscle, kidney, pancreas, prostate, testis, ovary, s

Database Links

HGNC: 17290

UNIGENE: Hs.132781

KEGG: hsa:9466

STRING: 9606.ENSP00000263379

OMIM: 605350

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