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Recombinant Human Interleukin-22 receptor subunit alpha-2 (IL22RA2)

Recombinant Human Interleukin-22 receptor subunit alpha-2 (IL22RA2)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

IL22RA2

Purity

>85% (SDS-PAGE)

Target Names

IL22RA2

Uniprot NO.

Q969J5

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

22-263

Target Protein Sequence

TQSTHESLK PQRVQFQSRN FHNILQWQPG RALTGNSSVY FVQYKIMFSC SMKSSHQKPS GCWQHISCNF PGCRTLAKYG QRQWKNKEDC WGTQELSCDL TSETSDIQEP YYGRVRAASA GSYSEWSMTP RFTPWWETKI DPPVMNITQV NGSLLVILHA PNLPYRYQKE KNVSIEDYYE LLYRVFIINN SLEKEQKVYE GAHRAVEIEA LTPHSSYCVV AEIYQPMLDR RSQRSEERCV EIP
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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■ Customer Reviews

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Target Background

Function(From Uniprot)

Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses.; Isoform 1 may play a role in establishing and maintaining successful pregnancy.

Gene References into Functions

expression higher in the epidermal compartment of the skin in comparison with dermis in both healthy skin and psoriasis skin PMID:27676439
suggest that the human IL-22BP isoforms have distinct spatial and temporal roles and coordinately fine-tune IL-22-dependent STAT3 responses in tissues as a type of rheostat. PMID:27678220
thia study shows shows that nonaffected skin of psoriasis patients displays lower expression of IL-22BP than skin of healthy controls, and that the strong IL-22 increase in lesional psoriatic skin is accompanied by a moderate induction of IL-22BP PMID:28356382
The deletion of IFNGR1 causes complete IFN-gammaR1 deficiency. Despite the deletion ending very close to the IL22RA2 gene, it does not appear to affect IL22RA2 transcription. PMID:26931784
IL-22BP is produced by eosinophils in the gut and blocks IL-22 protective actions in colitis. PMID:26329427
Through a combined approach including genetic and immunological investigation in an animal model and large-scale association studies of patients with multiple sclerosis (MS), IL-22RA2 is established as an MS risk gene. PMID:21041731
The IL-22R and IL-10R2 binding sites are juxtaposed on adjacent IL-22 surfaces contributed mostly by helices A, D, and F and loop AB. PMID:18675824
Crystallization and preliminary X-ray diffraction results of the IL-22-IL-22 binding protein (IL-22BP) complex are described. PMID:19193995
Polymorphisms in IL22RA1 are associated with severe CRS. PMID:19393422

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Subcellular Location

Secreted.

Protein Families

Type II cytokine receptor family

Tissue Specificity

Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placen

Database Links

HGNC: 14901

UNIGENE: Hs.126891

KEGG: hsa:116379

STRING: 9606.ENSP00000296980

OMIM: 606648

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