Recombinant Human Interleukin-17B (IL17B)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

IL17B

Purity

>85% (SDS-PAGE)

Target Names

IL17B

Uniprot NO.

Q9UHF5

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

21-180

Target Protein Sequence

QPRSPKSKRK GQGRPGPLAP GPHQVPLDLV SRMKPYARME EYERNIEEMV AQLRNSSELA QRKCEVNLQL WMSNKRSLSP WGYSINHDPS RIPVDLPEAR CLCLGCVNPF TMQEDRSMVS VPVFSQVPVR RRLCPPPPRT GPCRQRAVME TIAVGCTCIF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1.

Gene References into Functions

The results indicate that the IL-17B/IL-17RB signaling can promote the growth and migration of tumor cells. PMID:27146881
Our data revealed a new mechanism that IL-17B enhanced the progression of gastric cancer by activating mesenchymal stem cells. PMID:28145881
Segregation analysis revealed that variants c.475T>G in SKP1, c.671G>A in PROB1, and c.527G>A in IL17B in the 5q31.1-q35.3 linkage region, and c.850G>A in HKDC1 in the 10q22 locus completely segregated with the phenotype in the studied Keratoconus family PMID:27703147
This comprehensive review details the recognition of activity, signaling, and the roles of IL17B-IL17RB in breast cancer have caused to determination of new therapeutic mechanisms--{REVIEW} PMID:28160754
Studies indicate that interleukin 17 (IL-17B)/interleukin 17 receptor B (IL-17RB) signaling is essential for pancreatic cancer malignancy. PMID:26285835
IL-17B-IL-17RB signaling promotes pancreatic cancer malignancy. PMID:25732306
Results show that amplified signaling of interleukin-17 receptor B (IL-17RB) and its ligand IL-17B promot tumorigenicity in breast cancer cells and impeded acinus formation in immortalized normal mammary epithelial cells. PMID:23851503
IL-17B can enhance the effects of TNF-alpha on the production of cytokines and chemokines that control immune cell trafficking and neutrophil homeostasis in the inflamed tissues. PMID:24056520
IL-17A, IL-17B, IL-17F and IL-23 in systemic lupus erythematosus patients were examined and the correlation between levels of the investigated cytokines and VEGF, PIGF, as well as number of endothelial cells, was investigated. PMID:23661335
expression and functional study of IL-17B PMID:22394632
IL-17 may play an important role in the occurrence of nasal polyps by overexpression. PMID:16805377

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Subcellular Location

Secreted.

Protein Families

IL-17 family

Tissue Specificity

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

Database Links

HGNC: 5982

UNIGENE: Hs.156979

KEGG: hsa:27190

STRING: 9606.ENSP00000261796

OMIM: 604627

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