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Recombinant Human Integrin alpha-D (ITGAD), partial

Recombinant Human Integrin alpha-D (ITGAD), partial

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Source
Conjugate
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Target Background

Product Details

Abbreviation

ITGAD

Purity

>85% (SDS-PAGE)

Target Names

ITGAD

Uniprot NO.

Q13349

Alternative Names

ITGAD; Integrin alpha-D; ADB2; CD11 antigen-like family member D; Leukointegrin alpha D; CD antigen CD11d

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.

Gene References into Functions

findings suggest that CD11d/CD18 upregulation on proinflammatory macrophages may represent a common mechanism for macrophage retention at inflammatory sites, thereby promoting chronic inflammation and disease development. PMID:28500072
These results expand the potential for CD11d to regulate lymphocyte migration and tissue retention, and illuminate the possibility of a previously unconsidered role for CD11d in leukocyte biology and disease. PMID:27881604
alpha(D)beta(2) is a major member of the integrin repertoire of both circulating and tissue myeloid leukocytes in humans PMID:25415295
The effects of anti-CD11d treatment improves functional recovery in a rat model of repeated concussion. PMID:23414334
the cross-talk between neutrophils and NK cells is mediated by ICAM-3 and CD11d/CD18, respectively. PMID:21712539
CD11d expression increased in the subcutaneous white adipose tissue of obese adult women; this appears to be a common feature of obesity. PMID:21508205
a longer isoform of gut-enriched Kruppel-like factor 4 (GKLF) we term GKLFa interacts with the CD11d promoter PMID:15561714
multiple CD11d domains play a role in controlling intracellular location and association with CD18. PMID:19571252

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Integrin alpha chain family

Tissue Specificity

Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.

Database Links

HGNC: 6146

UNIGENE: Hs.679163

KEGG: hsa:3681

STRING: 9606.ENSP00000373854

OMIM: 602453

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