ITGAD Antibody

Code: CSB-PA011873GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: ELISA,WB

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Target Background

Product Details

Uniprot NO.

Q13349

Target Names

ITGAD

Alternative Names

ITGAD antibody; Integrin alpha-D antibody; ADB2 antibody; CD11 antigen-like family member D antibody; Leukointegrin alpha D antibody; CD antigen CD11d antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Human CD11d

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood.

Gene References into Functions

findings suggest that CD11d/CD18 upregulation on proinflammatory macrophages may represent a common mechanism for macrophage retention at inflammatory sites, thereby promoting chronic inflammation and disease development. PMID:28500072
These results expand the potential for CD11d to regulate lymphocyte migration and tissue retention, and illuminate the possibility of a previously unconsidered role for CD11d in leukocyte biology and disease. PMID:27881604
alpha(D)beta(2) is a major member of the integrin repertoire of both circulating and tissue myeloid leukocytes in humans PMID:25415295
The effects of anti-CD11d treatment improves functional recovery in a rat model of repeated concussion. PMID:23414334
the cross-talk between neutrophils and NK cells is mediated by ICAM-3 and CD11d/CD18, respectively. PMID:21712539
CD11d expression increased in the subcutaneous white adipose tissue of obese adult women; this appears to be a common feature of obesity. PMID:21508205
a longer isoform of gut-enriched Kruppel-like factor 4 (GKLF) we term GKLFa interacts with the CD11d promoter PMID:15561714
multiple CD11d domains play a role in controlling intracellular location and association with CD18. PMID:19571252

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Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Families

Integrin alpha chain family

Tissue Specificity

Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.

Database Links

HGNC: 6146

UNIGENE: Hs.679163

KEGG: hsa:3681

STRING: 9606.ENSP00000373854

OMIM: 602453

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