Recombinant Human Histone H2A-Bbd type 1 (H2AFB1)

Code
MSDS	MSDS
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

H2AFB1

Uniprot NO.

P0C5Y9

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

1-115

Target Protein Sequence

MPRRRRRRGS SGAGGRGRTC SRTVRAELSF SVSQVERSLR EGHYAQRLSR TAPVYLAAVI EYLTAKVPEL AGNEAQNSGE RNITPLLLDM VVHNDRLLST LFNTTTISQV APGED

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing.

Subcellular Location

Nucleus. Chromosome.

Protein Families

Histone H2A family

Tissue Specificity

Present in mature sperm.

Database Links

HGNC: 22516

UNIGENE: Hs.534498

KEGG: hsa:474382

STRING: 9606.ENSP00000346450

OMIM: 300445