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Recombinant Human HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA), partial

Recombinant Human HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA), partial

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

HLA-DOA

Uniprot NO.

P06340

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

Gene References into Functions

Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis PMID:27486778
significant association was found between white wine liking and rs9276975:C>T polymorphism in the HLA-DOA gene. PMID:25758996
TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population PMID:25874709
HLA-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies. PMID:24530695
HLA-DOA, HLA-DRA, and HLA-DQA1 associated with spontaneous autoimmunity PMID:24384427
results show that HLA-DO inhibits HLA-DM function by acting as a substrate mimic, and the findings also limit the possible functional roles for HLA-DO in antigen presentation PMID:23222639
analysis of the HLA-DO/HLA-DM complex by FRET and mutagenesis PMID:22733780
HLA-DOA mutations were analyzed for association with autoimmune diseases and B-cell leukemias. PMID:12439622
In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation. PMID:15265882
These results show that transduced DO modulates antigen presentation in human mature MoDC, evoking the possible use of this chaperone for immunotherapy. PMID:15817706
four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, were identified by sequence-based typing PMID:16101837
minor allele of the SNP rs9296068 is significantly associated with liver transplantation rejection and with enhanced B-lymphocyte participation in rejection, likely because of a dysfunctional HLA-DOA gene product. PMID:18639552
HLA-DOA polymorphisms are associated with Diabetes Mellitus, Type 1. PMID:19458622

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Subcellular Location

Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

Protein Families

MHC class II family

Database Links

HGNC: 4936

UNIGENE: Hs.631991

KEGG: hsa:3111

STRING: 9606.ENSP00000229829

OMIM: 142930

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