HLA-DOA Antibody

CSB-PA356784ESR1HU

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Size:

20μl50μl100μl

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC

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Target Background

Product Details

Uniprot NO.

P06340

Target Names

HLA-DOA

Alternative Names

HLA-DOA antibody; HLA-DNA antibody; HLA-DZAHLA class II histocompatibility antigen antibody; DO alpha chain antibody; MHC DN-alpha antibody; MHC DZ alpha antibody; MHC class II antigen DOA antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human HLA class II histocompatibility antigen, DO alpha chain protein (26-135AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Protocols

ELISA Protocol Immunohistochemistry (IHC) Protocol

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA356784ESR1HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skin tissue using CSB-PA356784ESR1HU at dilution of 1:100

Description

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Target Background

Function

Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B-cells. Modifies peptide exchange activity of HLA-DM.

Gene References into Functions

Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis PMID:27486778
significant association was found between white wine liking and rs9276975:C>T polymorphism in the HLA-DOA gene. PMID:25758996
TAP2, HLA-DOA, HLA-DOB, and tapasin loci are novel candidate regions for susceptibility to HCV infection and viral clearance in the Chinese population PMID:25874709
HLA-DO regulates surface presentation of human leukocyte antigen class II-restricted antigens on B cell malignancies. PMID:24530695
HLA-DOA, HLA-DRA, and HLA-DQA1 associated with spontaneous autoimmunity PMID:24384427
results show that HLA-DO inhibits HLA-DM function by acting as a substrate mimic, and the findings also limit the possible functional roles for HLA-DO in antigen presentation PMID:23222639
analysis of the HLA-DO/HLA-DM complex by FRET and mutagenesis PMID:22733780
HLA-DOA mutations were analyzed for association with autoimmune diseases and B-cell leukemias. PMID:12439622
In transgenic mice expressing human HLA-DOA & HLA-DOB from a DC-specific promoter, as DO increased, A(b)-CLIP increased & class II-peptides decreased. DO impaired H-2M function, causing Ag-specific downmodulation of class II Ag processing/presentation. PMID:15265882
These results show that transduced DO modulates antigen presentation in human mature MoDC, evoking the possible use of this chaperone for immunotherapy. PMID:15817706
four novel HLA-DOA alleles, DOA*010106, DOA*0102, DOA*0103, and DOA*0104N, were identified by sequence-based typing PMID:16101837
minor allele of the SNP rs9296068 is significantly associated with liver transplantation rejection and with enhanced B-lymphocyte participation in rejection, likely because of a dysfunctional HLA-DOA gene product. PMID:18639552
HLA-DOA polymorphisms are associated with Diabetes Mellitus, Type 1. PMID:19458622

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Subcellular Location

Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Complexes with HLA-DM molecule during intracellular transport and in endosomal/lysosomal compartments. Heterotetramerization is necessary to exit the ER.

Protein Families

MHC class II family

Database Links

HGNC: 4936

UNIGENE: Hs.631991

KEGG: hsa:3111

STRING: 9606.ENSP00000229829

OMIM: 142930

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