Recombinant Human HLA-B protein (HLA-B), partial

The recombinant Human HLA-B protein is encoded by the gene of HLA-B (25-308aa). The gene of HLA-B was cloned in a system (E.coli) that supported the expression of HLA-B. Modification of HLA-B by recombinant DNA technology could lead to the expression of the target protein. The protein was fused with N-terminal 6xHis tag in the production. The purity is 90% determined by SDS-PAGE.

HLA-B is a protein coding gene that encodes HLA-B protein. According to some studies, HLA-B may have the following features.
The dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA. Genetic variation in the HLA-B region and hypersensitivity to abacavir. The innate partnership of HLA-B and KIR3DL1 subtypes to HIV-1. Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B. A clone of a member of the immunoglobulin superfamily related to the recognition of HLA-C and HLA-B by human natural killer cells. The apparent interaction between KIR3DS1 and HLA-B delayed the development of AIDS. The assembly and maturation of HLA-A and HLA-B antigens in vivo. Reactivity of the Bw4 common epitope of the HLA-B molecule with natural killer cell clones expressing NKB1, a putative HLA receptor.