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Recombinant Human Glycine receptor subunit beta (GLRB), partial

Recombinant Human Glycine receptor subunit beta (GLRB), partial

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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

GLRB

Uniprot NO.

P48167

Alternative Names

GLRBGlycine receptor subunit beta; Glycine receptor 58 kDa subunit

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents.

Gene References into Functions

GLRB variants are associated with etiopathogenesis of fear and anxiety disorders. PMID:28872638
A genome-wide significant association was found between ACQ and single non-coding nucleotide variants of the GLRB gene (rs78726293, P = 3.3 x 10 - 8; rs191260602, P = 3.9 x 10- 8).GLRB gene expression was found to be modulated by rs7688285 in brain tissue, as well as cell culture. PMID:28167838
Whole-exome sequencing in ASD patients from each family identified a second rare inherited genetic variant, affecting GLRB expressed in inhibitory or in excitatory synapses. PMID:26055424
We report novel GLRB mutations in hyperekplexia PMID:23182654
Systematic DNA sequencing of GLRB in individuals with hyperekplexia revealed new missense mutations in GLRB, resulting in M177R, L285R and W310C substitutions. PMID:23238346
This study describes the definitive assignment of GLRB as the third major gene for hyperekplexia and impacts on the genetic stratification and biological causation of this neonatal/paediatric disorder. PMID:23184146
Distinct properties of glycine receptor beta+/alpha- interface: unambiguously characterizing heteromeric interface reconstituted in homomeric protein. PMID:22535951
This study presents a large family with Hereditary hyperekplexia (HH) as a result of homozygous mutation in GLRB. PMID:21391991
The authors have identified a protein kinase C (PKC) phosphorylation site within the cytoplasmic domain of the beta-subunit of the GlyR (residue S403) that causes a reduction of the binding affinity between the receptor and gephyrin. PMID:21829170
Stoichiometry of recombinant heteromeric glycine receptors revealed by a pore-lining region point mutation PMID:14698963

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Subcellular Location

Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite. Cell membrane; Multi-pass membrane protein. Cytoplasm.

Protein Families

Ligand-gated ion channel (TC 1.A.9) family, Glycine receptor (TC 1.A.9.3) subfamily, GLRB sub-subfamily

Database Links

HGNC: 4329

UNIGENE: Hs.32973

KEGG: hsa:2743

STRING: 9606.ENSP00000264428

OMIM: 138492

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