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Recombinant Human Glutamate receptor, ionotropic kainate 3 (GRIK3), partial

Recombinant Human Glutamate receptor, ionotropic kainate 3 (GRIK3), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

GRIK3

Purity

>85% (SDS-PAGE)

Target Names

GRIK3

Uniprot NO.

Q13003

Alternative Names

EAA5; Excitatory amino acid receptor 5; GLR 7; GLR7; GLU R7; GLUR 7; GluR 7a; GluR-7; GluR7; GluR7a; Glutamate receptor 7; Glutamate receptor; Glutamate receptor ionotropic kainate 3; GRIK 3; GRIK3; GRIK3_HUMAN; ionotropic kainate 3

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.

Gene References into Functions

additional experiment showed that the lymph node metastasis tissues had higher GRIK3 expression than their matched primary gastric cancer (GC) tissues. These findings suggested that elevated GRIK3 expression could serve as an independent prognostic biomarker and a novel potential treatment target for patients with GC. PMID:28631555
GRIK3 expression is significantly downregulated in human masticatory mucosa during wound healing PMID:28005267
1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay. PMID:24449200
Analyses revealed that polymorphism Ser310Ala of GRIK3 gene is not associated with alcohol dependence or any of its subgroups. PMID:23006490
Our results suggest that the analysed polymorphisms ofANKK1 and ADH4 can play an important part in the pathogenesis of alcohol abuse PMID:22232963
Some support (at a nominal significance level of 0.05/0.01) was found for association between GRIK3 and depression. PMID:20052609
Our study suggests a potential role for GRIK3 for susceptibility to schizophrenia in Indian population. PMID:19921975
Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia. PMID:11986986
suggestive for a significant role of GRIK3 polymorphism in the pathogenesis of delirium tremens in alcohol-dependent individuals PMID:16314883
These findings do not seem to support the hypothesis of the role of this polymorphism in the pathogenesis of alcoholism. PMID:16356644
significant linkage disequilibrium (LD) indicated by preferential maternal transmission of the GluR7 S310 allele to recurrent major depressive disorder patients (P = 0.012), but not to bipolar I disorder (BPI) patients (P = 1.00) PMID:16958029
The present results, although not robust, support the importance of more extensive investigations of GRIK3, given its potential role in mediating risk for schizophrenia. PMID:19022628
functional GRIK3 Ser310Ala polymorphism is homozygosity is associated with higher scores in harm avoidance and respective subscales of personality traits PMID:19221446