GRIK3 Antibody

Code: CSB-PA623779ESR1HU

Rate （5.0）
Review （1）
Citation （1）

Size:

20μl50μl100μl

US$83

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, WB, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

Q13003

Target Names

GRIK3

Alternative Names

EAA5 antibody; Excitatory amino acid receptor 5 antibody; GLR 7 antibody; GLR7 antibody; GLU R7 antibody; GLUR 7 antibody; GluR 7a antibody; GluR-7 antibody; GluR7 antibody; GluR7a antibody; Glutamate receptor 7 antibody; Glutamate receptor antibody; Glutamate receptor ionotropic kainate 3 antibody; GRIK 3 antibody; GRIK3 antibody; GRIK3_HUMAN antibody; ionotropic kainate 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Glutamate receptor ionotropic, kainate 3 protein (32-240AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western blot
All lanes: GRIK3 antibody at 1.45µg/ml
Lane 1: Hela whole cell lysate
Lane 2: K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 105, 99 kDa
Observed band size: 105 kDa
Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA623779ESR1HU at dilution of 1:100

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

Submit a Review here

Applications : Western blot

Sample type: Human Cells

Review: CircASXL1 knockdown-mediated repression on the protein expression of GRIK3 was restrained by miR-1205 inhibitor in SW480 and SW620 cells.

By Anonymous

Citations

CircASXL1 knockdown represses the progression of colorectal cancer by downregulating GRIK3 expression by sponging miR-1205 G Fang,/,2021

Target Background

Function(From Uniprot)

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds domoate > kainate >> L-glutamate = quisqualate >> AMPA = NMDA.

Gene References into Functions

additional experiment showed that the lymph node metastasis tissues had higher GRIK3 expression than their matched primary gastric cancer (GC) tissues. These findings suggested that elevated GRIK3 expression could serve as an independent prognostic biomarker and a novel potential treatment target for patients with GC. PMID:28631555
GRIK3 expression is significantly downregulated in human masticatory mucosa during wound healing PMID:28005267
1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay. PMID:24449200
Analyses revealed that polymorphism Ser310Ala of GRIK3 gene is not associated with alcohol dependence or any of its subgroups. PMID:23006490
Our results suggest that the analysed polymorphisms ofANKK1 and ADH4 can play an important part in the pathogenesis of alcohol abuse PMID:22232963
Some support (at a nominal significance level of 0.05/0.01) was found for association between GRIK3 and depression. PMID:20052609
Our study suggests a potential role for GRIK3 for susceptibility to schizophrenia in Indian population. PMID:19921975
Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia. PMID:11986986
suggestive for a significant role of GRIK3 polymorphism in the pathogenesis of delirium tremens in alcohol-dependent individuals PMID:16314883
These findings do not seem to support the hypothesis of the role of this polymorphism in the pathogenesis of alcoholism. PMID:16356644
significant linkage disequilibrium (LD) indicated by preferential maternal transmission of the GluR7 S310 allele to recurrent major depressive disorder patients (P = 0.012), but not to bipolar I disorder (BPI) patients (P = 1.00) PMID:16958029
The present results, although not robust, support the importance of more extensive investigations of GRIK3, given its potential role in mediating risk for schizophrenia. PMID:19022628
functional GRIK3 Ser310Ala polymorphism is homozygosity is associated with higher scores in harm avoidance and respective subscales of personality traits PMID:19221446