Recombinant Human Gamma-aminobutyric acid receptor subunit alpha-6 (GABRA6), partial

1. TMEM132D, COMT and GABRA6 gene polymorphisms may influence susceptibility to panic disorder(PD) and major depressive disorder(MDD)in Japanese adults; these variants may increase vulnerability to PD by modulating oligodendrocytes and GABA and dopaminergic functions in related brain regions, altering neuronal processing of anxiety-related emotional signals PMID:25974322
2. NOS3, GABRA6, child abuse, neighborhood crime Gene x Gene, Environment x Environment, and Gene x Environment interactions are associated with different patterns of respiratory sinus arrhythmia reactivity. PMID:26535938
3. The gene-gene interaction at two loci involving GABRA6 and Synapsin II revealed a significant association for development of idiopathic generalized epilepsy. PMID:25088614
4. genetic association study in Chinese Han population: Data suggest an SNP in GABRA6 (rs3219151) is associated with decreased predisposition to schizophrenia via alteration of miroRNA binding to target in 3-prime-untranslated region of GABRA6 mRNA. PMID:23332465
5. GABRA6 mutation, R46W, was identified as a susceptibility gene that may contribute to the pathogenesis of childhood absence epilepsy and cause neuronal disinhibition and increase in seizures via a reduction of alphabetagamma and alphabetadelta receptor function and expression PMID:21930603
6. Part of the interindividual differences observed for anxiety traits measured by the Harm Avoidance dimension could be explained by the GABRA6 gene variability. PMID:21902679
7. significant involvement of alpha (GABRA6) and beta (GABRB2) subunits of GABA(A) receptor in epilepsy susceptibility in north Indian population PMID:21420396
8. studies have found prefrontal cortical GABA(A) receptor alpha subunit alterations in schizophrenia PMID:20100621
9. These findings support a role for the serotonin transporter and GABA(A) alpha6 subunit in depression-related traits. PMID:14744464
10. The T1521C polymorphism in the GABRA6 gene is associated with specific personality characteristics as well as a marked attenuation in hormonal and blood pressure responses to psychological stress. PMID:15197399
11. GABRA6 expression is regulated by NFI in cerebellar granule neurons PMID:15466411
12. Findings support a role for GABRA6 (Pro385Ser) in perceived parenting. PMID:16402352
13. Polymorphism not associated with panic disorder. PMID:17167337
14. Chinese patients with certain psychiatric characteristics and GABRA6 heterozygosity are probably predisposed to functional heartburn PMID:17295876
15. The T allele of the 1519T>C GABA(A)alpha6 gene may be one of the modulating factors associated with changes in craving for alcohol and food during treatment of patients with alcohol dependence. PMID:18616664
16. Significant matching effects were found for polymorphisms at the DRD2, GABRA6 and GABRB2 gene. In addition, a trend was found for the OPRM1 polymorphism. PMID:19523047

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HGNC: 4080

UNIGENE: Hs.90791

KEGG: hsa:2559

STRING: 9606.ENSP00000274545

OMIM: 137143