GABRA6 Antibody

Code: CSB-PA002619

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Size:

50μg100μg

US$119

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Species Reactivity: Human,Mouse,Rat

Raised in: Rabbit

Application: WB, ELISA

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Target Background

Product Details

Uniprot NO.

Q16445

Target Names

GABRA6

Alternative Names

GABA A antibody; GABA A Receptor alpha 6 polypeptide antibody; GABA A receptor alpha 6 antibody; GABA A receptor subunit alpha 6 antibody; GABA subunit A receptor alpha 6 antibody; GABA(A) receptor subunit alpha-6 antibody; GABRA 6 antibody; GABRA6 antibody; Gamma aminobutyric acid A receptor alpha 6 antibody; Gamma aminobutyric acid GABA A receptor alpha 6 antibody; Gamma aminobutyric acid receptor subunit alpha 6 antibody; Gamma-aminobutyric acid receptor subunit alpha-6 antibody; GBRA6_HUMAN antibody; MGC116903 antibody; MGC116904 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from the Internal region of Human GABAA Rα6.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Tested Applications

WB, ELISA

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Images

Western Blot analysis of MOUSE-BRAIN cells using GABAA Rα6 Polyclonal Antibody
Western Blot analysis of MOUSE-BRAIN cells using GABAA Rα6 Polyclonal Antibody

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Target Background

Function(From Uniprot)

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Gene References into Functions

TMEM132D, COMT and GABRA6 gene polymorphisms may influence susceptibility to panic disorder(PD) and major depressive disorder(MDD)in Japanese adults; these variants may increase vulnerability to PD by modulating oligodendrocytes and GABA and dopaminergic functions in related brain regions, altering neuronal processing of anxiety-related emotional signals PMID:25974322
NOS3, GABRA6, child abuse, neighborhood crime Gene x Gene, Environment x Environment, and Gene x Environment interactions are associated with different patterns of respiratory sinus arrhythmia reactivity. PMID:26535938
The gene-gene interaction at two loci involving GABRA6 and Synapsin II revealed a significant association for development of idiopathic generalized epilepsy. PMID:25088614
genetic association study in Chinese Han population: Data suggest an SNP in GABRA6 (rs3219151) is associated with decreased predisposition to schizophrenia via alteration of miroRNA binding to target in 3-prime-untranslated region of GABRA6 mRNA. PMID:23332465
GABRA6 mutation, R46W, was identified as a susceptibility gene that may contribute to the pathogenesis of childhood absence epilepsy and cause neuronal disinhibition and increase in seizures via a reduction of alphabetagamma and alphabetadelta receptor function and expression PMID:21930603
Part of the interindividual differences observed for anxiety traits measured by the Harm Avoidance dimension could be explained by the GABRA6 gene variability. PMID:21902679
significant involvement of alpha (GABRA6) and beta (GABRB2) subunits of GABA(A) receptor in epilepsy susceptibility in north Indian population PMID:21420396
studies have found prefrontal cortical GABA(A) receptor alpha subunit alterations in schizophrenia PMID:20100621
These findings support a role for the serotonin transporter and GABA(A) alpha6 subunit in depression-related traits. PMID:14744464
The T1521C polymorphism in the GABRA6 gene is associated with specific personality characteristics as well as a marked attenuation in hormonal and blood pressure responses to psychological stress. PMID:15197399
GABRA6 expression is regulated by NFI in cerebellar granule neurons PMID:15466411
Findings support a role for GABRA6 (Pro385Ser) in perceived parenting. PMID:16402352
Polymorphism not associated with panic disorder. PMID:17167337
Chinese patients with certain psychiatric characteristics and GABRA6 heterozygosity are probably predisposed to functional heartburn PMID:17295876
The T allele of the 1519T>C GABA(A)alpha6 gene may be one of the modulating factors associated with changes in craving for alcohol and food during treatment of patients with alcohol dependence. PMID:18616664
Significant matching effects were found for polymorphisms at the DRD2, GABRA6 and GABRB2 gene. In addition, a trend was found for the OPRM1 polymorphism. PMID:19523047