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Recombinant Human G2 and S phase-expressed protein 1 (GTSE1)

Recombinant Human G2 and S phase-expressed protein 1 (GTSE1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

GTSE1

Purity

>85% (SDS-PAGE)

Target Names

GTSE1

Uniprot NO.

Q9NYZ3

Alternative Names

GTSE1; G2 and S phase-expressed protein 1; GTSE-1; Protein B99 homolog

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

1-720

Target Protein Sequence

MDDPKKEDIL LLADEKFDFD LSLSSSSANE DDEVFFGPFG HKERCIAASL ELNNPVPEQP PLPTSESPFA WSPLAGEKFV EVYKEAHLLA LHIESSSRNQ AAQAAKPEDP RSQGVERFIQ ESKLKINLFE KEKEMKKSPT SLKRETYYLS DSPLLGPPVG EPRLLASSPA LPSSGAQARL TRAPGPPHSA HALPRESCTA HAASQAATQR KPGTKLLLPR AASVRGRSIP GAAEKPKKEI PASPSRTKIP AEKESHRDVL PDKPAPGAVN VPAAGSHLGQ GKRAIPVPNK LGLKKTLLKA PGSTSNLARK SSSGPVWSGA SSACTSPAVG KAKSSEFASI PANSSRPLSN ISKSGRMGPA MLRPALPAGP VGASSWQAKR VDVSELAAEQ LTAPPSASPT QPQTPEGGGQ WLNSSCAWSE SSQLNKTRSI RRRDSCLNSK TKVMPTPTNQ FKIPKFSIGD SPDSSTPKLS RAQRPQSCTS VGRVTVHSTP VRRSSGPAPQ SLLSAWRVSA LPTPASRRCS GLPPMTPKTM PRAVGSPLCV PARRRSSEPR KNSAMRTEPT RESNRKTDSR LVDVSPDRGS PPSRVPQALN FSPEESDSTF SKSTATEVAR EEAKPGGDAA PSEALLVDIK LEPLAVTPDA ASQPLIDLPL IDFCDTPEAH VAVGSESRPL IDLMTNTPDM NKNVAKPSPV VGQLIDLSSP LIQLSPEADK ENVDSPLLKF
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.

Gene References into Functions

G2 and S-phase expressed 1 (GTSE1) expression promotes AM progression and correlates with clinical outcomes of patients with acral melanoma (AM), and may represent a promising therapeutic target to suppress AM progression. PMID:29660787
GTSE1 is expressed exclusively in late G2 and M phase. From nuclear envelope breakdown until anaphase onset, GTSE1 binds preferentially to the most stable mitotic spindle microtubules and promotes their turnover. PMID:28821562
Results indicated for the first time that overexpression of GTSE1 was involved in the progress of HCC, enhancing proliferation and promoting cell invasion in HCC cells. PMID:27240802
Study identifies GTSE1 as a biomarker for cisplatin resistance in gastric cancer cells and suggests its repressive role in cisplatin induced apoptosis making it a potential therapeutic target for better clinical management of gastric cancer patients. PMID:26209226
GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration. PMID:23236459
GTSE1 is overexpressed dramatically in lung cancer patients' tissues. PMID:22292647
Data show that G2 and S-phase-expressed 1 (GTSE1) protein, a negative regulator of p53, is required for G2 checkpoint recovery and that Plk1 phosphorylation of GTSE1 promotes its nuclear localization. PMID:20577264
hGTSE-1 mediated-p21(CIP1/WAF1) stabilization is clearly involved in the ability of cells to counteract cytotoxicity induced by the microtubule poison paclitaxel. PMID:20018861
GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function PMID:12750368
requires an intact nuclear export signal and functional Mdm2 for the regulation of p53 PMID:14707141