GTSE1 Antibody

Code: CSB-PA010041GA01HU

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Size:

100μl

US$600

Quantity:

Species Reactivity: Human

Raised in: Rabbit

Application: ELISA,WB,IF

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Target Background

Product Details

Uniprot NO.

Q9NYZ3

Target Names

GTSE1

Alternative Names

GTSE1 antibody; G2 and S phase-expressed protein 1 antibody; GTSE-1 antibody; Protein B99 homolog antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Human GTSE1

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA,WB,IF

Protocols

ELISA Protocol Western Blotting(WB) Protocol Immunofluorescence (IF) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression.

Gene References into Functions

G2 and S-phase expressed 1 (GTSE1) expression promotes AM progression and correlates with clinical outcomes of patients with acral melanoma (AM), and may represent a promising therapeutic target to suppress AM progression. PMID:29660787
GTSE1 is expressed exclusively in late G2 and M phase. From nuclear envelope breakdown until anaphase onset, GTSE1 binds preferentially to the most stable mitotic spindle microtubules and promotes their turnover. PMID:28821562
Results indicated for the first time that overexpression of GTSE1 was involved in the progress of HCC, enhancing proliferation and promoting cell invasion in HCC cells. PMID:27240802
Study identifies GTSE1 as a biomarker for cisplatin resistance in gastric cancer cells and suggests its repressive role in cisplatin induced apoptosis making it a potential therapeutic target for better clinical management of gastric cancer patients. PMID:26209226
GTSE1 is a microtubule plus-end tracking protein that regulates EB1-dependent cell migration. PMID:23236459
GTSE1 is overexpressed dramatically in lung cancer patients' tissues. PMID:22292647
Data show that G2 and S-phase-expressed 1 (GTSE1) protein, a negative regulator of p53, is required for G2 checkpoint recovery and that Plk1 phosphorylation of GTSE1 promotes its nuclear localization. PMID:20577264
hGTSE-1 mediated-p21(CIP1/WAF1) stabilization is clearly involved in the ability of cells to counteract cytotoxicity induced by the microtubule poison paclitaxel. PMID:20018861
GTSE-1 controls DNA damage-induced apoptosis by affecting p53 function PMID:12750368
requires an intact nuclear export signal and functional Mdm2 for the regulation of p53 PMID:14707141