Recombinant Human G-protein coupled receptor 4 (GPR4), partial

1. Proton-sensing GPR4 signaling mediated the proton-induced inhibitory effects on the osteogenesis of BMSCs. YAP was the downstream effector of GPR4 signaling. Extracellular pH modulates the osteogenic responses of BMSCs by regulating the proton-sensing GPR4-YAP pathway. PMID:27256071
2. These results suggest that zOGR1, but not GPR4, is also a metal-sensing G-protein-coupled receptor in addition to a proton-sensing G-protein-coupled receptor, although not all metals that activate hOGR1 activated zOGR1. PMID:28270026
3. GPR4 blockade attenuated renal injury after IR and reduced the cell apoptosis through the suppression of CHOP expression. PMID:29089376
4. acidosis/GPR4-induced endoplasmic reticulum stress pathways in endothelial cells may regulate vascular growth and inflammatory response in the acidic microenvironment. PMID:28134810
5. it was demonstrated that GPR4 affects ECs by regulating Notch1, a function that may be important for physiological and pathological angiogenesis. PMID:27279286
6. GPR4 induces angiogenesis via GPR4-induced p38-mediated IL6, IL8 and VEGFA secretion at acidic extracellular pH in squamous cell carcinoma of the head and neck PMID:27078157
7. The results suggested that GPR4 may play an important role in the development of epithelial ovarian carcinoma (EOC), and its overexpression might be required for the angiogenesis, tumor growth, and metastasis of EOC PMID:23888957
8. acidosis/GPR4 signaling regulates endothelial cell adhesion mainly through the G(s)/cAMP/Epac pathway PMID:22110680
9. The mutation of histidine residue at 79, 165, or 269 from the N-terminal of GPR4 to phenylalanine shifted the half-maximal effective concentration (EC(50)) of proton-induced signaling activities to the right, including cAMP accumulation. PMID:20211729
10. Endogenous GPR4 in endothelial cells may be a potential G protein-coupled receptor by which LPC signals proinflammatory activities. PMID:12805023
11. GPR4, a close relative of OGR1, also responds to pH changes, but elicits cyclic AMP formation PMID:12955148
12. sphingosylphosphorylcholine and lysophosphatidic acid are not the ligands for GPR4 and that this receptor may constitutively inhibit ERK1/2 activation PMID:14567679
13. GPR4 and TDAG8 overexpression in human tumors plays a role in driving or maintaining tumor formation PMID:15221007
14. results identify sphingosylphosphorylcholine and its receptor, G protein-coupled receptor 4(GPR4), as critical regulators of the angiogenic potential of endothelial cells PMID:15857892
15. GPR4 may play a critical role in the inflammatory responses activated by lysophosphatidylcholine PMID:16461426
16. GPR4 in brain endothelial cells regulates monocyte transmigration. PMID:17364894
17. lysophosphatidylcholine receptor G protein-coupled receptor 4 (GPK4) was expressed in YPEN-1 cells and triggered the cAMP/protein kinase A/cAMP response element-binding protein pathway, resulting in upregulation of adhesion molecules. PMID:17437524
18. Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. PMID:17462861

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HGNC: 4497

UNIGENE: Hs.17170

KEGG: hsa:2828

STRING: 9606.ENSP00000319744

OMIM: 600551