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Recombinant Human ETS domain-containing protein Elk-3 (ELK3)

Recombinant Human ETS domain-containing protein Elk-3 (ELK3)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ELK3

Uniprot NO.

P41970

Alternative Names

ELK3; ELK3; ETS domain protein (SRF accessory protein 2); ELK3_HUMAN; ERP; ETS domain protein; ETS domain-containing protein Elk-3; ETS related protein ERP; ETS related protein NET; ETS-related protein ERP; ETS-related protein NET; NET; SAP 2; SAP-2; SAP2; Serum response factor accessory protein 2; SRF accessory protein 2

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

1-407

Target Protein Sequence

MESAITLWQF LLQLLLDQKH EHLICWTSND GEFKLLKAEE VAKLWGLRKN KTNMNYDKLS RALRYYYDKN IIKKVIGQKF VYKFVSFPEI LKMDPHAVEI SRESLLLQDS DCKASPEGRE AHKHGLAALR STSRNEYIHS GLYSSFTINS LQNPPDAFKA IKTEKLEEPP EDSPPVEEVR TVIRFVTNKT DKHVTRPVVS LPSTSEAAAA SAFLASSVSA KISSLMLPNA ASISSASPFS SRSPSLSPNS PLPSEHRSLF LEAACHDSDS LEPLNLSSGS KTKSPSLPPK AKKPKGLEIS APPLVLSGTD IGSIALNSPA LPSGSLTPAF FTAQTPNGLL LTPSPLLSSI HFWSSLSPVA PLSPARLQGP STLFQFPTLL NGHMPVPIPS LDRAASPVLL SSNSQKS
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Gene References into Functions

Decreased Net expression characterize on-small-cell lung cancer progression. PMID:19483189
Net might play an important role in pancreatic carcinogenesis PMID:23469073
These results suggest that the ELK3-GATA3 axis is a major pathway that promotes metastasis of breast cancer MDA-MB-231 cells PMID:27556500
The expression levels of Elk-3 in liver cirrhosis tissues were significantly higher than those in chronic hepatitis tissues. PMID:27538444
We revealed that activation of the PI3K/Akt pathway was the main cause of impaired autophagy in ELK3 KD. Our results suggest that targeting ELK3 may be a potential approach to overcome doxorubicin resistance in breast cancer therapeutics. PMID:27301639
Taken together, we suggest that ELK3 is an upstream regulator of the NF-kappaB signaling pathway, the inhibition of which leads to the suppression of peritumoral lymphatic vessel development, possibly due to a low VEGFC expression. PMID:28188790
High expression of ELK3 is associated with migration and invasion of liver cancer stem cells. PMID:27959451
results suggest that ELK3 plays a positive role in the metastasis of BC cells by indirectly regulating MT1-MMP expression PMID:26637400
The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PMID:25401928
ELK3 plays a negative role of VEGF-induced angiogenesis through indirectly inhibiting ETS-1 function. PMID:24719561
Net and HIF1alpha are components of distinct signaling pathways that are intricately linked PMID:20427288
the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles PMID:18316589
These findings suggested that loss of Net repression could augment c-fos expression and further trigger neoplastic cell proliferation, which was involved in the pathogenesis of pancreatic cancer. PMID:18832796