Phospho-ELK3 (S357) Antibody

Code: CSB-PA008025

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Size:

50μg100μg

US$119

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Species Reactivity: Human,Mouse,Monkey

Raised in: Rabbit

Application: WB, IHC, IF, ELISA

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Product Details
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Target Background

Product Details

Uniprot NO.

P41970

Target Names

ELK3

Alternative Names

ELK3 antibody; ELK3; ETS domain protein (SRF accessory protein 2) antibody; ELK3_HUMAN antibody; ERP antibody; ETS domain protein antibody; ETS domain-containing protein Elk-3 antibody; ETS related protein ERP antibody; ETS related protein NET antibody; ETS-related protein ERP antibody; ETS-related protein NET antibody; NET antibody; SAP 2 antibody; SAP-2 antibody; SAP2 antibody; Serum response factor accessory protein 2 antibody; SRF accessory protein 2 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Monkey

Immunogen

Synthesized peptide derived from Human Net around the phosphorylation site of S357.

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

WB, IHC, IF, ELISA

Protocols

Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol Immunofluorescence (IF) Protocol ELISA Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot analysis of COLO cells using Phospho-Net (S357) Polyclonal Antibody

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Target Background

Function(From Uniprot)

May be a negative regulator of transcription, but can activate transcription when coexpressed with Ras, Src or Mos. Forms a ternary complex with the serum response factor and the ETS and SRF motifs of the Fos serum response element.

Gene References into Functions

Decreased Net expression characterize on-small-cell lung cancer progression. PMID:19483189
Net might play an important role in pancreatic carcinogenesis PMID:23469073
These results suggest that the ELK3-GATA3 axis is a major pathway that promotes metastasis of breast cancer MDA-MB-231 cells PMID:27556500
The expression levels of Elk-3 in liver cirrhosis tissues were significantly higher than those in chronic hepatitis tissues. PMID:27538444
We revealed that activation of the PI3K/Akt pathway was the main cause of impaired autophagy in ELK3 KD. Our results suggest that targeting ELK3 may be a potential approach to overcome doxorubicin resistance in breast cancer therapeutics. PMID:27301639
Taken together, we suggest that ELK3 is an upstream regulator of the NF-kappaB signaling pathway, the inhibition of which leads to the suppression of peritumoral lymphatic vessel development, possibly due to a low VEGFC expression. PMID:28188790
High expression of ELK3 is associated with migration and invasion of liver cancer stem cells. PMID:27959451
results suggest that ELK3 plays a positive role in the metastasis of BC cells by indirectly regulating MT1-MMP expression PMID:26637400
The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PMID:25401928
ELK3 plays a negative role of VEGF-induced angiogenesis through indirectly inhibiting ETS-1 function. PMID:24719561
Net and HIF1alpha are components of distinct signaling pathways that are intricately linked PMID:20427288
the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles PMID:18316589
These findings suggested that loss of Net repression could augment c-fos expression and further trigger neoplastic cell proliferation, which was involved in the pathogenesis of pancreatic cancer. PMID:18832796