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Recombinant Human EGF-like module-containing mucin-like hormone receptor-like 1 (EMR1), partial

Recombinant Human EGF-like module-containing mucin-like hormone receptor-like 1 (EMR1), partial

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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ADGRE1

Uniprot NO.

Q14246

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Description

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Target Background

Function

Orphan receptor involved in cell adhesion and probably in cell-cell interactions specifically involving cells of the immune system. May play a role in regulatory T-cells (Treg) development.

Gene References into Functions

EMR1 expression is significantly upregulated in human masticatory mucosa during wound healing PMID:28005267
Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included increased EMR1&3. PMID:20625511
Highly specific marker for eosinophils. PMID:17823986

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 2 family, Adhesion G-protein coupled receptor (ADGR) subfamily

Tissue Specificity

Expression is restricted to eosinophils.

Database Links

HGNC: 3336

UNIGENE: Hs.2375

KEGG: hsa:2015

STRING: 9606.ENSP00000311545