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Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3), partial

Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

CREB3L3

Purity

>85% (SDS-PAGE)

Target Names

CREB3L3

Uniprot NO.

Q68CJ9

Alternative Names

CREB3L3; CREBH; HYST1481Cyclic AMP-responsive element-binding protein 3-like protein 3; cAMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3]

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription.

Gene References into Functions

CREBH has a crucial role in glucose and lipid metabolism in the liver and small intestine. PMID:29738435
Beta-TrCP controls ubiquitination and degradation of liver-enriched transcription factor CREB-H. PMID:27029215
Identify a novel pathogenic mutation in CREB3L3 gene in a family with dominant hypertriglyceridemia with a variable pattern of penetrance. PMID:26427795
CREBH activated by HBx interacted with HBx protein, leading to a synergistic effect on the expression of AP-1 target genes and the proliferation of hepatocellular carcinoma cells and mouse primary hepatocytes. PMID:25428452
Taken together, our results demonstrated that human APOA5 is directly regulated by CREBH via CREBHRE and provided a new insight into the role of this liver-specific bZIP transcription factor in lipoprotein metabolism and triglyceride homeostasis PMID:23957007
Studies indicate that mutations in CREB3L3 in individuals with extreme hypertriglyceridemia. PMID:22262056
a novel mechanism of action of activated CB1R signaling to induce hepatic gluconeogenesis via direct activation of CREBH PMID:21693703
Levels of CREB transcripts did NOT significantly differ in the thyroid adenomas and surrounding normal tissues. PMID:12039695
analysis of CREB-H trafficking into alternate pathways of ERAD and stress-regulated intramembrane proteolysis PMID:17875199
findings show that CREBH an endoplasmic reticulum stress-activated transcription factor, binds to and transactivates the hepcidin promoter PMID:19679815

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Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Protein Families

BZIP family, ATF subfamily

Tissue Specificity

Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.

Database Links

HGNC: 18855

UNIGENE: Hs.247744

KEGG: hsa:84699

STRING: 9606.ENSP00000078445

OMIM: 611998

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