CREB3L3 Antibody

Code: CSB-PA912582

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Size:

50μg100μg

US$119

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Species Reactivity: Human, Mouse, Rat

Application: ELISA, WB

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Target Background

Product Details

Uniprot NO.

Q68CJ9

Target Names

CREB3L3

Alternative Names

Cyclic AMP-responsive element-binding protein 3-like protein 3, cAMP-responsive element-binding protein 3-like protein 3, Transcription factor CREB-H, Processed cyclic AMP-responsive element-binding protein 3-like protein 3, CREB3L3, CREBH, HYST1481

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from part region of human protein

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, WB

Recommended Dilution

Application	Recommended Dilution
WB	1:200-1:1000

Protocols

ELISA Protocol Western Blotting(WB) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

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Target Background

Function(From Uniprot)

Transcription factor that may act during endoplasmic reticulum stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. In vitro, binds to the cAMP response element (CRE) and box-B element. Activates transcription through box-B element. Activates transcription through CRE. May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription.

Gene References into Functions

CREBH has a crucial role in glucose and lipid metabolism in the liver and small intestine. PMID:29738435
Beta-TrCP controls ubiquitination and degradation of liver-enriched transcription factor CREB-H. PMID:27029215
Identify a novel pathogenic mutation in CREB3L3 gene in a family with dominant hypertriglyceridemia with a variable pattern of penetrance. PMID:26427795
CREBH activated by HBx interacted with HBx protein, leading to a synergistic effect on the expression of AP-1 target genes and the proliferation of hepatocellular carcinoma cells and mouse primary hepatocytes. PMID:25428452
Taken together, our results demonstrated that human APOA5 is directly regulated by CREBH via CREBHRE and provided a new insight into the role of this liver-specific bZIP transcription factor in lipoprotein metabolism and triglyceride homeostasis PMID:23957007
Studies indicate that mutations in CREB3L3 in individuals with extreme hypertriglyceridemia. PMID:22262056
a novel mechanism of action of activated CB1R signaling to induce hepatic gluconeogenesis via direct activation of CREBH PMID:21693703
Levels of CREB transcripts did NOT significantly differ in the thyroid adenomas and surrounding normal tissues. PMID:12039695
analysis of CREB-H trafficking into alternate pathways of ERAD and stress-regulated intramembrane proteolysis PMID:17875199
findings show that CREBH an endoplasmic reticulum stress-activated transcription factor, binds to and transactivates the hepcidin promoter PMID:19679815

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Subcellular Location

Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.

Protein Families

BZIP family, ATF subfamily

Tissue Specificity

Exclusively expressed in liver. Underexpressed in hepatocellular carcinoma tissues.

Database Links

HGNC: 18855

UNIGENE: Hs.247744

KEGG: hsa:84699

STRING: 9606.ENSP00000078445

OMIM: 611998

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