Recombinant Human Complement C1q tumor necrosis factor-related protein 1 (C1QTNF1)

1. CTRP1 has a role in linking dysregulation of lipid metabolism and inflammatory responses in macrophages PMID:27175610
2. High serum CTRP1 level is associated with Type 2 diabetes mellitus. PMID:28207876
3. In cultured endothelial cells, treatment of CTRP1 led to increased permeability to fluorescent-labelled dextran and apparent formation of paracellular holes as observed after disturbed flow exposure, which was evidently reduced in the presence of a CTRP1-specific neutralizing antibody. PMID:28625919
4. Increased serum CTRP 1 levels were closely associated with the prevalence and severity of CAD, it might be regarded as a marker for myocardial infarction. PMID:27169633
5. the strong association of CTRP1 with insulin resistance in NAFLD PMID:25767880
6. The levels of circulating CTRP1 are associated with coronary artery disease in men. PMID:24945145
7. The variation of plasma CTRP-1 and IL-6 concentrations may play an important role in reflecting the degree of inflammation in CHD and the severity of coronary arterial atherosclerosis. PMID:25635749
8. Increased plasma CTRP1 was independently associated with type 2 diabetes. Profiling of plasma adipokines such as CTRP1 is particularly important to obtain a greater understanding of their contribution to the type 2 diabetic state. PMID:24965225
9. CTRP1 is a novel adipokine associated with type 2 diabetes mellitus in humans. PMID:24827430
10. CTRP1 level was significantly higher in subjects with metabolic syndrome compared to healthy subjects. PMID:23000311
11. The review describes the potential role of C1qTNF1 as an intracellular regulator of signal transduction PMID:16386877
12. molecular cloning, gene expression, and subcellular localization of GIP PMID:12409230
13. These findings indicate that CTRP1 expression may be associated with a low-grade chronic inflammation status in adipose tissues. PMID:16806199
14. CTRP1 enhances the production of aldosterone. CTRP1 was highly expressed in obese subjects as well as up-regulated in hypertensive patients, CTRP1 may be a newly identified molecular link between obesity and hypertension. PMID:18171693
15. CTRP1 may be considered a novel adipokine, providing an important framework to further address the physiological functions and mechanisms of the action of this family of secreted glycoproteins in normal and disease states. PMID:18783346

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HGNC: 14324

UNIGENE: Hs.201398

KEGG: hsa:114897

STRING: 9606.ENSP00000340864

OMIM: 610365