Recombinant Human Cohesin subunit SA-2 (STAG2), partial

1. STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection. PMID:29662124
2. STAG2 loss of Expression is Associated with Cancer Progression in Upper Urinary Tract Carcinoma. PMID:28967037
3. these data suggest that STAG2 acts as a tumor suppressor gene in bladder cancer and may be a potential therapeutic target in bladder cancer PMID:28627627
4. Extending the lifespan of normal human cells due to inactivation of STAG2 could promote tumorigenesis by extending the period during which tumor-driving mutations occur. PMID:28819029
5. TAG2 is the most commonly mutated subunit, and in a recent analysis was identified as one of only 12 genes that are significantly mutated in four or more cancer types. PMID:27207471
6. the clinical features of these three cases are remarkably similar to those observed in other well-established cohesinopathies. Herein, we suggest that STAG2 is a dosage-sensitive gene and that heterozygous loss-of-function variants lead to a cohesinopathy. PMID:28296084
7. results indicated that the complete loss of STAG2 expression was predictive for better recurrence-free survival and cancer-specific survival, suggesting its potential value as a prognostic biomarker in bladder cancer PMID:26838030
8. We suggest that increased STAG2 gene copy number and dysregulation of its downstream target genes may be responsible for the specific clinical findings of this syndrome. PMID:25677961
9. Characterization of C-terminal nuclear localization signal of the human SA2 stromalin PMID:25979289
10. Data show a significantly higher stromal antigen 2 (STAG2) mRNA and protein levels in normal bladder cells than bladder cancer cells. PMID:25867412
11. Microduplication of chromosome Xq25 encompassing STAG2 gene in a boy with intellectual disability PMID:25450604
12. STAG2 promotes the correction of kMT attachment errors to ensure faithful chromosome segregation during mitosis. PMID:25074805
13. Genomic landscape of Ewing sarcoma defines an aggressive subtype with co-association of STAG2 and TP53 mutations PMID:25223734
14. Loss of STAG2 expression occurs in 15% of tumors and is associated with metastatic disease, suggesting a potential genetic vulnerability in Ewing sarcoma PMID:25186949
15. our study identifies the duplication of XIAP and STAG2 as the minimal duplicated region leading to the ID, facial morphological anomalies, and speech delay, specific to the patients with Xq25 duplication. PMID:24733578
16. In an independent EFT tissue microarray cohort, we show that STAG2 loss as detected by immunohistochemistry may be associated with more advanced disease (p = 0.15) and a modest decrease in overall survival (p = 0.10). PMID:25010205
17. Aneuploidy in human salivary gland carcinomas is not driven by loss of expression of STAG2. PMID:24822266
18. These data suggest that PARP is a potential target for tumors harboring inactivating mutations in STAG2, and strongly recommend that STAG2 status be determined and correlated with therapeutic response to PARP inhibitors PMID:24356817
19. Cross-sectional deep-sequencing analysis for clonal hierarchy demonstrated STAG2, SMC3, and RAD21 mutations to be ancestral in 18%, 18%, and 47% of cases, respectively, and each expanded to clonal dominance concordant with disease transformation PMID:25006131
20. Loss of STAG2 function is associated with non-invasive bladder cancer. PMID:24270882
21. Mutations in STAG2 is associated with acute myeloid leukemia. PMID:24335498
22. STAG2 is one of the most commonly mutated genes in bladder cancer. PMID:24121789
23. STAG2 is a new urothelial bladder cancer tumor suppressor acting through mechanisms that are different from its role in preventing aneuploidy. PMID:24121791
24. Inactivating point mutations in the STAG2 gene are not common in neuroblastoma tumors PMID:24088605
25. Somatic mutation of STAG2, an aneuploidy-related gene, is rare in acute leukemias. PMID:22132872
26. Low STAG2 expression and not mutation is associated with neoplasms. PMID:22668012
27. study has shown that diverse human cancers harbor mutations in the X-linked chromatid cohesion gene STAG2 and that these mutations cause aneuploidy PMID:21852505
28. evidence suggests STAG2 functions as a transcriptional co-activator by a mechanism involving protein-protein interactions with transcription factors PMID:14660624
29. Phosphorylation of SA2 is essential for cohesin dissociation during prophase and prometaphase, but is not required for cohesin cleavage by separase. PMID:15737063
30. Cohesion between sister chromatids is essential for their bi-orientation on mitotic spindles is mediated by a multisubunit complex called cohesin. PMID:15737064

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Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of cohesin is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex.

SCC3 family

HGNC: 11355

UNIGENE: Hs.496710

KEGG: hsa:10735

STRING: 9606.ENSP00000218089

OMIM: 300826