Recombinant Human Citrate synthase, mitochondrial (CS)

1. citrate synthase and ACSS1 have tumorigenic functions in hepatocellular carcinoma PMID:27363021
2. Citrate synthase activity was lower in patients with heart failure with preserved ejection fraction compared to controls. PMID:27179829
3. mir-122 and its targets G6PC3, ALDOA and CS play roles in the hypoxia responses that regulate glucose and energy metabolism and can serve as hypoxia biomarkers. PMID:27793029
4. METTL12 methylates CS on Lys-395, which is localized in the CS active site. Interestingly, the METTL12-mediated methylation inhibited CS activity and was blocked by the CS substrate oxaloacetate. PMID:28887308
5. Data suggest that METTL12, localized in mitochondrial matrix, modifies/methylates Lys368 of citrate synthase in external surface region close to its catalytic site; addition/removal of methylation has no effect on citrate synthase activity; Lys368 occurs in highly conserved sequence of amino acid residues of citrate synthase. (METTL12 = methyltransferase-like protein 12) PMID:28391595
6. Data suggest that downregulation of citrate synthase (CS) expression in 293T cells leads to low level of ATP production, excessive superoxide formation and cell apoptosis, which implies a possible mechanism for hearing loss in A/J mice. PMID:28216161
7. Hence, we conclude that SIRT3 exhibits neuroprotection via deacetylating and increasing mitochondrial enzyme activities. PMID:28161643
8. Paretic muscle in hemiparetic stroke survivors had lower CS concentration. PMID:26361074
9. The citrate synthase knockdown cells exhibited severe defects in respiratory activity and marked decreases in ATP production, but great increases in glycolytic metabolism. PMID:23139858
10. Citrate synthase (CS) is a direct RORalpha target gene and one mechanism by which RORalpha regulates lipid metabolism is via regulation of CS expression. PMID:22485150
11. Responses of skeletal and cardiac muscles in CS activity and gene expression at 1 and 48 h after endurance training. Acute effect of exercise on training-induced elevation in CS activity in rat soleus but not ventricle muscles. PMID:12531911
12. possible role of CS-specific autoantibodies in the pathomechanism of allograft vasculopathy PMID:15711981
13. It is likely that enhanced citrate synthase activity contributes to the conversion of glucose to lipids in pancreatic cancer providing substrate for membrane lipids synthesis. PMID:15714131
14. These results provide an important basis for the study of mitochondrial dysfunction due to aberrant CSa trafficking. PMID:19479947

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HGNC: 2422

UNIGENE: Hs.743252

KEGG: hsa:1431

STRING: 9606.ENSP00000342056

OMIM: 118950