Recombinant Human Calcium-activated potassium channel subunit beta-1 (KCNMB1), partial

1. Expression of vascular large-conductance calcium-activated potassium channel Kcnmb1 is regulated by Nrf2 signaling. PMID:28429615
2. The study demonstrates that both transmembrane domains of BKbeta1 are required to provide the characteristic ion current phenotype of beta1-containing BK channels. PMID:25275635
3. Data show that two lysine residues that are unique to the N terminus of calcium-activated potassium channel subunit beta-1 were identified to be sufficient for voltage-sensor modulation. PMID:25825713
4. To determine the relationship between atherosclerosis and KCNMB1, we studied some atherogenic factors affecting vascular tone. Blood of atherosclerotic patients shows increased concentration of 7-ketocholesterol, possibly a harmful lipid to blood vessels. PMID:25576871
5. Bisphenol A activates BK alpha via an extracellular site and that Bisphenol A-sensitivity is increased by the beta1 subunit. PMID:24476761
6. In large-conductance calcium-dependent potassium channels, beta1 and beta2 subunits alter the voltage sensing domain-cytosolic domain interface. PMID:23825428
7. The results indicate that the beta1-subunit can form a tripartite complex with TP and MaxiKalpha, has the ability to associate with each protein independently. PMID:23255603
8. HIF-1alpha increases KCNMB1 expression in response to hypoxia in human pulmonary artery smooth muscle cells by binding to two hypoxia response elements located at -3,540 to -3,311 of the KCNMB1 promoter PMID:22114151
9. Here we found that KCNMB1 common variant Glu65Lys influences glomerular filtration rate across multiple populations of different clinical characteristics and biogeographic ancestries. PMID:20861615
10. downregulation of vascular BK-beta(1) expression in diabetes and in high-glucose culture conditions was associated with FOXO-3a/FBXO-dependent increase in BK-beta(1) degradation. PMID:20966391
11. Results reveal the first ion channel subunit as a direct target of SRF-MYOCD transactivation, providing further insight into the role of MYOCD as a master regulator of the SMC contractile phenotype. PMID:19801679
12. Phosphorylation-dependent functional coupling of hSlo and its hbeta 4 subunit PMID:11790768
13. have a reset baroreflex. Variants in the gene (KCNMB1) coding for the BK beta1 subunit are associated with baroreflex function. PMID:12011654
14. mesangial cells contain hbeta1, a BK accessory protein, which confers activation of BK by cGMP kinase. PMID:12670831
15. Beta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanisms. PMID:12893878
16. We conclude that transient membrane current is generated by a mechanism related to the deactivation, and level of prior activation, of glioma BK channels. PMID:12962281
17. results reveal the molecular regions in the beta1 and beta2 subunits that determine their differential functional coupling with the pore-forming alpha-subunit PMID:16446507
18. identified and characterized single nucleotide polymorphisms in the exons, intron/exon junctions, upstream region and 3' untranslated regions of KCNMB1 using denaturing high-performance liquid chromatography combined with direct DNA sequencing PMID:17496725
19. The protective effect of KCNMB1 E65K against hypertension is restricted to blood pressure treatment with beta-blockade. PMID:18418400
20. African American male asthmatics carrying the KCNMB1 818T allele (10% of population) are potentially at risk for greater airway obstruction and increased asthma morbidity. PMID:18535015
21. The findings suggest that the KCNMB1 Glu65Lys polymorphism associates with reduced systolic and diastolic blood pressure in middle-aged men. PMID:18854753
22. The KCNMB1 E65K variant is associated with reduced central pulse pressure. PMID:19050450
23. maxi-K(+) beta1-subunit could contribute to vascular dysregulation in severe obstructive sleep apnea syndrome patients. Leukocyte beta1 expression may be independent readout of hypoxemia that could be useful as molecular marker for impending hypertension. PMID:19057512
24. Cell membrane stretch and cell volume sensitivity are independently regulated by KCNMB1 (BK) and KCNQ1 channels, respectively. PMID:19289549
25. genetic polymorphism shows sex-specific association with asthma severity in male african population PMID:19295429

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HGNC: 6285

UNIGENE: Hs.484099

KEGG: hsa:3779

STRING: 9606.ENSP00000274629

OMIM: 603951