Recombinant Human Adenosine kinase (ADK)

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

ADK

Uniprot NO.

P55263

Species

Homo sapiens (Human)

Source

Yeast

Expression Region

2-362

Target Protein Sequence

AAAEEEPKP KKLKVEAPQA LRENILFGMG NPLLDISAVV DKDFLDKYSL KPNDQILAED KHKELFDELV KKFKVEYHAG GSTQNSIKVA QWMIQQPHKA ATFFGCIGID KFGEILKRKA AEAHVDAHYY EQNEQPTGTC AACITGDNRS LIANLAAANC YKKEKHLDLE KNWMLVEKAR VCYIAGFFLT VSPESVLKVA HHASENNRIF TLNLSAPFIS QFYKESLMKV MPYVDILFGN ETEAATFARE QGFETKDIKE IAKKTQALPK MNSKRQRIVI FTQGRDDTIM ATESEVTAFA VLDQDQKEII DTNGAGDAFV GGFLSQLVSD KPLTECIRAG HYAASIIIRR TGCTFPEKPD FH
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

Gene References into Functions

The results of this study showed that over-expression of the major adenosine removing enzyme ADK in reactive astrocytes and subpopulation of remaining neurons in Rasmussen Encephalitis patients plays an important role in the epileptogensis of Rasmussen Encephalitis. PMID:28789481
rs11001109 rare allele homozygosity is associated with increased risk of post-traumatic epilepsy development after brain injury. PMID:26040919
The results of this study suggest that upregulation of ADK is a common pathologic component of FCDIIB. PMID:25575137
These results suggest that upregulation of ADK is a common pathologic hallmark of Rasmussen encephalitis and that ADK might be a target in the treatment of epilepsy associated with Rasmussen encephalitis. PMID:24128682
Data show that we a significantly higher expression of ADK in the peritumoral infiltrated tissue of patients with epilepsy than in patients without epilepsy. PMID:22092111
The results of this study suggested that dysregulation of ADK in astrocytes is a common pathologic hallmark of temporal lobe epilepsy. PMID:21635241
The cytoplasmic isoform of adenosine kinase is sufficient to alter sleep physiology. ADK might orchestrate neurotransmitter pathways involved in the generation of electroencephlogram oscillations and regulation of sleep. PMID:20881134
The catalytic properties, gene expression and protein levels of certain proteins involved in mitochondrial ATP synthesis, such as F1F0-ATPase, ANT and AK, in human skin fibroblasts with trisomic karyotype, compared them with euploid fibroblasts. PMID:20698827
Equilibrative nucleoside transporters (hENT1, hENT2) together with adenosine kinase and 5'-nucleotidase play a crucial role in the regulation of CFTR through an adenosine-dependent pathway in human airway epithelia. PMID:12820662
role for HIF-1alpha in transcriptional repression of AK in hypoxia PMID:18309031
adenosine kinase gene expression was significantly higher in cancer than in normal-appearing tissue, in line with our previous measurements of adenosine kinase enzyme activities in colorectal tumor samples PMID:18600536
both deoxycytidine kinase and adenosine kinase are involved in this model of ADA deficiency PMID:18600545
This study reports for the first time subcellular localization of the enzyme AdK in mammalian cells. PMID:19635462