ADK Antibody

Code: CSB-PA346232LA01HU

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US$83

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Species Reactivity: Human, Mouse, Rat

Raised in: Rabbit

Application: ELISA, WB, IHC, IF

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Product Details
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Target Background

Product Details

Uniprot NO.

P55263

Target Names

ADK

Alternative Names

2310026J05Rik antibody; 5033405D03Rik antibody; Adenosine 5''-phosphotransferase antibody; Adenosine kinase antibody; adk antibody; ADK_HUMAN antibody; AI255373 antibody; AI987814 antibody; AK antibody; MGC6593 antibody; OTTHUMP00000019864 antibody; OTTHUMP00000019865 antibody

Raised in

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant Human Adenosine kinase protein (18-256AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB, IHC, IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:5000
IHC	1:20-1:200
IF	1:50-1:200

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Western Blot
Positive WB detected in: HL60 whole cell lysate, Rat kidney tissue, Rat liver tissue, Mouse kideny tissue, Mouse liver tissue
All lanes: ADK antibody at 3μg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 41, 39, 35, 37 kDa
Observed band size: 41 kDa
Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA346232LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA346232LA01HU at dilution of 1:100
Immunofluorescent analysis of PC-3 cells using CSB-PA346232LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives. Serves as a potential regulator of concentrations of extracellular adenosine and intracellular adenine nucleotides.

Gene References into Functions

The results of this study showed that over-expression of the major adenosine removing enzyme ADK in reactive astrocytes and subpopulation of remaining neurons in Rasmussen Encephalitis patients plays an important role in the epileptogensis of Rasmussen Encephalitis. PMID:28789481
rs11001109 rare allele homozygosity is associated with increased risk of post-traumatic epilepsy development after brain injury. PMID:26040919
The results of this study suggest that upregulation of ADK is a common pathologic component of FCDIIB. PMID:25575137
These results suggest that upregulation of ADK is a common pathologic hallmark of Rasmussen encephalitis and that ADK might be a target in the treatment of epilepsy associated with Rasmussen encephalitis. PMID:24128682
Data show that we a significantly higher expression of ADK in the peritumoral infiltrated tissue of patients with epilepsy than in patients without epilepsy. PMID:22092111
The results of this study suggested that dysregulation of ADK in astrocytes is a common pathologic hallmark of temporal lobe epilepsy. PMID:21635241
The cytoplasmic isoform of adenosine kinase is sufficient to alter sleep physiology. ADK might orchestrate neurotransmitter pathways involved in the generation of electroencephlogram oscillations and regulation of sleep. PMID:20881134
The catalytic properties, gene expression and protein levels of certain proteins involved in mitochondrial ATP synthesis, such as F1F0-ATPase, ANT and AK, in human skin fibroblasts with trisomic karyotype, compared them with euploid fibroblasts. PMID:20698827
Equilibrative nucleoside transporters (hENT1, hENT2) together with adenosine kinase and 5'-nucleotidase play a crucial role in the regulation of CFTR through an adenosine-dependent pathway in human airway epithelia. PMID:12820662
role for HIF-1alpha in transcriptional repression of AK in hypoxia PMID:18309031
adenosine kinase gene expression was significantly higher in cancer than in normal-appearing tissue, in line with our previous measurements of adenosine kinase enzyme activities in colorectal tumor samples PMID:18600536
both deoxycytidine kinase and adenosine kinase are involved in this model of ADA deficiency PMID:18600545
This study reports for the first time subcellular localization of the enzyme AdK in mammalian cells. PMID:19635462