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Recombinant Human ATP-binding cassette sub-family A member 5 (ABCA5), partial

Recombinant Human ATP-binding cassette sub-family A member 5 (ABCA5), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Abbreviation

ABCA5

Purity

>85% (SDS-PAGE)

Target Names

ABCA5

Uniprot NO.

Q8WWZ7

Alternative Names

ABC13; ABCA5; ABCA5_HUMAN; ATP binding cassette sub family A (ABC1) member 5; ATP binding cassette A5; ATP binding cassette sub family A member 5; ATP-binding cassette sub-family A member 5; DKFZp451F117; DKFZp779N2435; EST90625; FLJ16381; KIAA1888

Species

Homo sapiens (Human)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes.

Gene References into Functions

This report represents the first extensive expression and functional study of ABCA5 in the human brain and our data suggest a plausible function of ABCA5 in the brain as a cholesterol transporter associated with Abeta generation PMID:25125465
our findings support ABCA5 as a gene underlying the congenital generalized hypertrichosis terminalis phenotype and suggest a novel, previously unrecognized role for this gene in regulating hair growth. PMID:24831815
The expression of ABCA5 was significantly elevated in parkinson disease brains compared to age- and gender-matched control brains. PMID:23939407
The ABCB5 gene may be related to the properties of chemoresistance and aggressiveness of melanoma PMID:20487690
Cloning of ABCA5 and detection of a splice variant. PMID:12504089
ABCA5 may have a role in prostatic intraepithelial neoplasia PMID:17289887
There is a correlation of induction of ABCA5 and mRNA with differentiation of colonic neoplasms. PMID:17541169

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Subcellular Location

Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell membrane.

Protein Families

ABC transporter superfamily, ABCA family

Tissue Specificity

Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta. Expressed in both the epithelial and mesenchymal compartments, present within the outer root sheath (ORS) of the hair follicle as well as dermal sheath. Expre

Database Links

HGNC: 35

UNIGENE: Hs.731824

KEGG: hsa:23461

STRING: 9606.ENSP00000376443

OMIM: 612503

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