ABCA5 Antibody

Code: CSB-PA845163LA01HU

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20μg50μg100μg

US$83

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Species Reactivity: Human

Raised in: Rabbit

Application: ELISA, IHC

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Product Details
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Target Background

Product Details

Uniprot NO.

Q8WWZ7

Target Names

ABCA5

Alternative Names

ABC13 antibody; ABCA5 antibody; ABCA5_HUMAN antibody; ATP binding cassette sub family A (ABC1) member 5 antibody; ATP binding cassette A5 antibody; ATP binding cassette sub family A member 5 antibody; ATP-binding cassette sub-family A member 5 antibody; DKFZp451F117 antibody; DKFZp779N2435 antibody; EST90625 antibody; FLJ16381 antibody; KIAA1888 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human ATP-binding cassette sub-family A member 5 protein (1230-1355AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol Immunohistochemistry (IHC) Protocol

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Datasheet & COA

Antibody FAQs

Images

Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA845163LA01HU at dilution of 1:100
Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA845163LA01HU at dilution of 1:100

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes.

Gene References into Functions

This report represents the first extensive expression and functional study of ABCA5 in the human brain and our data suggest a plausible function of ABCA5 in the brain as a cholesterol transporter associated with Abeta generation PMID:25125465
our findings support ABCA5 as a gene underlying the congenital generalized hypertrichosis terminalis phenotype and suggest a novel, previously unrecognized role for this gene in regulating hair growth. PMID:24831815
The expression of ABCA5 was significantly elevated in parkinson disease brains compared to age- and gender-matched control brains. PMID:23939407
The ABCB5 gene may be related to the properties of chemoresistance and aggressiveness of melanoma PMID:20487690
Cloning of ABCA5 and detection of a splice variant. PMID:12504089
ABCA5 may have a role in prostatic intraepithelial neoplasia PMID:17289887
There is a correlation of induction of ABCA5 and mRNA with differentiation of colonic neoplasms. PMID:17541169

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Subcellular Location

Golgi apparatus membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell membrane.

Protein Families

ABC transporter superfamily, ABCA family

Tissue Specificity

Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta. Expressed in both the epithelial and mesenchymal compartments, present within the outer root sheath (ORS) of the hair follicle as well as dermal sheath. Expre

Database Links

HGNC: 35

UNIGENE: Hs.731824

KEGG: hsa:23461

STRING: 9606.ENSP00000376443

OMIM: 612503

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