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Recombinant Equine infectious anemia virus Gag polyprotein (gag)

Recombinant Equine infectious anemia virus Gag polyprotein (gag)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

gag

Uniprot NO.

P69731

Species

Equine infectious anemia virus (isolate CL22) (EIAV)

Source

Yeast

Expression Region

1-124

Target Protein Sequence

MGDPLTWSKA LKKLEKVTVQ GSQKLTTGNC NWALSLVDLF HDTNFVKEKD WQLRDVIPLL EDVTQTLSGQ EREAFERTWW AISAVKMGLQ INNVVDGKAS FQLLRAKYEK KTANKKQSEP SEEY
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

full length protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

Store at -20°C, for extended storage, conserve at -20°C or -80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Matrix protein p15 forms the outer shell of the core of the virus, lining the inner surface of the viral membrane.; Capsid protein p26 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.; Nucleocapsid protein p11 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers.; p9 plays a role in budding of the assembled particle by interacting with PDCD6IP/AIP1.

Gene References into Functions

Equine infectious anemia virus Gag is sumoylated at lysine 30 of its p9 domain. PMID:28342872
Then, the authors determined that W7 and K9 in the equine infectious anemia virus matrix protein N terminus were essential for Gag assembly and release but did not affect the cellular distribution of Gag. PMID:26637458
EIAV p9 Gag protein mediates virus release by recruiting the ALG2-interacting protein X (ALIX) via the YPDL-motif to the site of virus budding, the counterpart of the YPXnL-motif found in p6. PMID:20015412
lentivirus assembly and budding are regulated by the RNA nuclear export pathway and alternative cellular pathways can be adapted for lentiviral Gag assembly and budding. PMID:17686839
A phylogenetic analysis based on 414nts of Gag gene sequences amplified by a nested PCR revealed the distinct divergence of these variants compared to other published strains in a corresponding region PMID:17767972