gag Antibody

Code: CSB-PA304026XA01EFT

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Equine infectious anemia virus (isolate CL22) (EIAV)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

P69731

Target Names

gag

Alternative Names

gag antibody; Gag polyprotein [Cleaved into: Matrix protein p15 antibody; MA); Capsid protein p26 antibody; CA); p1; Nucleocapsid protein p11 antibody; NC); p9] antibody

Raised in

Rabbit

Species Reactivity

Equine infectious anemia virus (isolate CL22) (EIAV)

Immunogen

Recombinant Equine infectious anemia virus (isolate CL22) (EIAV) gag protein

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Matrix protein p15 forms the outer shell of the core of the virus, lining the inner surface of the viral membrane.; Capsid protein p26 forms the conical core of the virus that encapsulates the genomic RNA-nucleocapsid complex.; Nucleocapsid protein p11 encapsulates and protects viral dimeric unspliced (genomic) RNA. Binds these RNAs through its zinc fingers.; p9 plays a role in budding of the assembled particle by interacting with PDCD6IP/AIP1.

Gene References into Functions

Equine infectious anemia virus Gag is sumoylated at lysine 30 of its p9 domain. PMID:28342872
Then, the authors determined that W7 and K9 in the equine infectious anemia virus matrix protein N terminus were essential for Gag assembly and release but did not affect the cellular distribution of Gag. PMID:26637458
EIAV p9 Gag protein mediates virus release by recruiting the ALG2-interacting protein X (ALIX) via the YPDL-motif to the site of virus budding, the counterpart of the YPXnL-motif found in p6. PMID:20015412
lentivirus assembly and budding are regulated by the RNA nuclear export pathway and alternative cellular pathways can be adapted for lentiviral Gag assembly and budding. PMID:17686839
A phylogenetic analysis based on 414nts of Gag gene sequences amplified by a nested PCR revealed the distinct divergence of these variants compared to other published strains in a corresponding region PMID:17767972