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Recombinant Drosophila melanogaster Palmitoyl-protein thioesterase 1 (Ppt1)

Recombinant Drosophila melanogaster Palmitoyl-protein thioesterase 1 (Ppt1)

Code
MSDS	MSDS Datasheet
Size	Pls inquire
Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Ppt1

Purity

>85% (SDS-PAGE)

Target Names

Ppt1

Uniprot NO.

Q9W3C7

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

26-314

Target Protein Sequence

YIWWS PTKGGTNPEV LPVVLWHGMG DTCCVPFSLG AIMNLIVEQT KGGYVRSLQI GGNVLIDWQS GFFIHPNEQV DYVCKQLLQD EHLAKGYHAI GFSQGGQFLR AVAERCPNPP MRNLITLGGQ HQGIFGLPMC PTLTEKPCDY ITRLLDNAAY APEVQKALVQ ATYWHDPIME NKYRLGSTFL ADINNELFIN KFYIENLQKL KKFVMVQFLN DTIVQPKESQ WFQYYTTGQN KVIQPFTESK VYQDLGLDKM HRQGQLVFLG VEGDHLAISK AWFIQNIVPL LLEK
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Full Length of Mature Protein

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Customer Reviews and Q&A

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Target Background

Function(From Uniprot)

Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides.

Gene References into Functions

Ppt1 has a role in synaptic vesicle exo- and endocytosis at motor nerve terminals of the Drosophila neuromuscular junction. PMID:24091420
Palmitoyl Protein Thioesterase 1 gene regulates neural specification and axon connectivity during Drosophila embryonic development PMID:21203506
An unbiased dominant loss-of-function genetic modifier screen is performed in Drosophila using a previously characterized Ppt1 gain-of-function system. PMID:20206262
major lysosomal thioesterase; Ppt2 expression cannot rescue neural inclusion phenotypes associated with loss of Ppt1 PMID:18719403
Increased levels of DmPpt1 lead to neurodegeneration possibly via a detrimentl effect on some aspect of PPT1's normal function. This suggests that the precise levels of PPT1 activity are important for neuronal cell survival. PMID:14629778
Ppt1 has a role in accumulation of storage material and in life span but not in preventing neurodegeneration PMID:16452138
Modifier genes identified in this screen connect Ppt1 function to synaptic vesicle cycling, endo-lysosomal trafficking, synaptic development, and activity-dependent remodeling of the synapse. PMID:17409080