Ppt1 Antibody

Code: CSB-PA018587XA01DLU

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Size:

0.1ml

0.1ml1ml

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Species Reactivity: Drosophila melanogaster (Fruit fly)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q9W3C7

Target Names

Ppt1

Alternative Names

Ppt1 antibody; CG12108 antibody; Palmitoyl-protein thioesterase 1 antibody; PPT-1 antibody; EC 3.1.2.22 antibody; Palmitoyl-protein hydrolase 1 antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Ppt1 protein

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

Datasheet & COA

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Target Background

Function(From Uniprot)

Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides.

Gene References into Functions

Ppt1 has a role in synaptic vesicle exo- and endocytosis at motor nerve terminals of the Drosophila neuromuscular junction. PMID:24091420
Palmitoyl Protein Thioesterase 1 gene regulates neural specification and axon connectivity during Drosophila embryonic development PMID:21203506
An unbiased dominant loss-of-function genetic modifier screen is performed in Drosophila using a previously characterized Ppt1 gain-of-function system. PMID:20206262
major lysosomal thioesterase; Ppt2 expression cannot rescue neural inclusion phenotypes associated with loss of Ppt1 PMID:18719403
Increased levels of DmPpt1 lead to neurodegeneration possibly via a detrimentl effect on some aspect of PPT1's normal function. This suggests that the precise levels of PPT1 activity are important for neuronal cell survival. PMID:14629778
Ppt1 has a role in accumulation of storage material and in life span but not in preventing neurodegeneration PMID:16452138
Modifier genes identified in this screen connect Ppt1 function to synaptic vesicle cycling, endo-lysosomal trafficking, synaptic development, and activity-dependent remodeling of the synapse. PMID:17409080