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Recombinant Drosophila melanogaster Nuclear factor NF-kappa-B p110 subunit (Rel), partial

Recombinant Drosophila melanogaster Nuclear factor NF-kappa-B p110 subunit (Rel), partial

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Source
Conjugate
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Product Details
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Target Background

Product Details

Abbreviation

Rel

Purity

>85% (SDS-PAGE)

Target Names

Rel

Uniprot NO.

Q94527

Alternative Names

Rel; CG11992; Nuclear factor NF-kappa-B p110 subunit; Rel-p110; Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit; Rel-p68); Nuclear factor NF-kappa-B p49 subunit; Rel-p49)]

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Expression Region

1-971

Target Protein Sequence

MNMNQYYDLD NGKNVMFMND ASSTSGYSSS TSPNSTNRSF SPAHSPKTME LQTDFANLNL PGGNSPHQPP MANSPYQNQL LNNGGICQLG ATNLINSTGV SFGVANVTSF GNMYMDHQYF VPAPATVPPS QNFGYHQNGL ASDGDIKHVP QLRIVEQPVE KFRFRYKSEM HGTHGSLNGA NSKRTPKTFP EVTLCNYDGP AVIRCSLFQT NLDSPHSHQL VVRKDDRDVC DPHDLHVSKE RGYVAQFINM GIIHTAKKYI FEELCKKKQD RLVFQMNRRE LSHKQLQELH QETEREAKDM NLNQVRLCFE AFKIEDNGAW VPLAPPVYSN AINNRKSAQT GELRIVRLSK PTGGVMGNDE LILLVEKVSK KNIKVRFFEE DEDGETVWEA YAKFRESDVH HQYAIVCQTP PYKDKDVDRE VNVYIELIRP SDDERSFPAL PFRYKPRSVI VSRKRRRTGS SANSSSSGTE SSNNSLDLPK TLGLAQPPNG LPNLSQHDQT ISEEFGREKH LNEFIASEDF RKLIEHNSSD LEKICQLDMG ELQHDGHNRA EVPSHRNRTI KCLDDLFEIY KQDRISPIKI SHHKVEKWFI EHALNNYNRD TLLHEVISHK KDKLKLAIQT IQVMNYFNLK DVVNSTLNAD GDSALHVACQ QDRAHYIRPL LGMGCNPNLK NNAGNTPLHV AVKEEHLSCV ESFLNGVPTV QLDLSLTNDD GLTPLHMAIR QNKYDVAKKL ISYDRTSISV ANTMDGNNAL HMAVLEQSVE LLVLILDAQN ENLTDILQAQ NAAGHTPLEL AERKANDRVV QLLKNVYPEK GELAMTWIPC KVKEEIDSSS DESSDAGQLE IKSEEMDIET KDEDSVELDL SSGPRRQKDE SSRDTEMDNN KLQLLLKNKF IYDRLCSLLN QPLGHGSDPQ DRKWMQLARQ THLKQFAFIW LGAEDLLDHV KRKGASVEFS TFARALQAVD PQAYALLVNP T
Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage Condition

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

Plays a key role in the humoral immune response. Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes. I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation. Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system. Possibly post-transcriptionally regulates the neuron-specific genes sc and ase, by promoting the rapid turnover of their transcripts in the wing imaginal disk.

Gene References into Functions

Early gene Broad complex(BR-C) could be regulating the immune pathways by activating Relish and physically interacting with it to activate antimicrobial peptides expression. PMID:25931442
The Toll/NF-kappaB signaling pathway is required for epidermal wound repair in Drosophila. PMID:25427801
Epistatic analysis indicates that DMAP1 acts in parallel or downstream of Relish. PMID:24947515
the IMD/Relish signaling pathway is a central regulator of microbiota-mediated transcriptional response PMID:24733183
Relish mutations inhibited upregulation of innate immune response genes and neurodegeneration in ATM mutants. PMID:23502677
induction of antimicrobial peptide expression is via activation of the NF-kappaB transcription factor Relish in the immune deficiency (Imd) pathway PMID:22470576
NF-kappaB transcription factor Relish mediates the alternative pathway of cell death in Drosophila PMID:22328149
Data show that inhibition of NF-kappaB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively. PMID:21483034
Ectopic Ras/MAPK pathway activation results in the suppression of Drosophila IMD/NF-kappaB signalling. PMID:21297578
immune response increases sleep in flies in a manner that is gated by the circadian clock and that requires the NFkappaB Relish; supports a role of sleep in a recovery process and demonstrate a conserved feature of the Drosophila model of sleep. PMID:20144235
activation is controlled by PGRP-LC PMID:11872802
Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in larvae. PMID:12359879
a caspase target site, located in the linker region between the Rel and the IkappaB-like domain, is the site of signal-dependent cleavage PMID:12732719
Rel synergy with GATA plays a pervasive role in the immune response. PMID:14731391
Rel limits duration of JNK activation in response to Gram-neg infections. Rel activation is linked to TAK1 degradation, terminating JNK signaling, resulting in a transient JNK-dependent response that precedes sustained induction of immune loci. PMID:15037551
Molecular modeling was used to compare the tertiary structure of Relish with two other Drosophila proteins. PMID:17785540
the C-terminal IkappaB-like domain executes a scaffolding and recruiting function for full activation of Relish. PMID:19135474
show that the IKK complex controls Relish by direct phosphorylation on serines 528 and 529. Surprisingly, these phosphorylation sites are not required for Relish cleavage, nuclear translocation, or DNA binding PMID:19497884

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Subcellular Location

[Nuclear factor NF-kappa-B p68 subunit]: Nucleus.; [Nuclear factor NF-kappa-B p110 subunit]: Cytoplasm.; [Nuclear factor NF-kappa-B p49 subunit]: Cytoplasm.

Database Links

UNIGENE: Dm.4154

KEGG: dme:Dmel_CG11992

STRING: 7227.FBpp0088375

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