Rel Antibody

Code: CSB-PA856705XA01DLU

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0.1ml

0.1ml1ml

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Species Reactivity: Drosophila melanogaster (Fruit fly)

Raised in: Rabbit

Application: ELISA, WB (ensure identification of antigen)

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Target Background

Product Details

Uniprot NO.

Q94527

Target Names

Rel

Alternative Names

Rel antibody; CG11992 antibody; Nuclear factor NF-kappa-B p110 subunit antibody; Rel-p110 antibody; Relish protein) [Cleaved into: Nuclear factor NF-kappa-B p68 subunit antibody; Rel-p68); Nuclear factor NF-kappa-B p49 subunit antibody; Rel-p49)] antibody

Raised in

Rabbit

Species Reactivity

Drosophila melanogaster (Fruit fly)

Immunogen

Recombinant Drosophila melanogaster (Fruit fly) Rel protein

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Tested Applications

ELISA, WB (ensure identification of antigen)

Lead Time

Made-to-order (14-16 weeks)
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Value-added Deliverables

① 200ug * antigen (positive control);
② 1ml * Pre-immune serum (negative control);

Quality Guarantee

① Antibody purity can be guaranteed above 90% by SDS-PAGE detection;
② ELISA titer can be guaranteed 1: 64,000;
③ WB validation with antigen can be guaranteed positive;

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Target Background

Function(From Uniprot)

Plays a key role in the humoral immune response. Rel-p68 subunit translocates to the nucleus where it binds to the promoter of the Cecropin A1 gene and probably other antimicrobial peptide genes. I-kappa-B kinase complex (IKKbeta and key) and PGRP-LC are essential signaling components in transmitting the lipopolysaccharide (LPS) signal leading to cact degradation for NF-kappa-B (rel) activation. Part of a Toll-related receptor pathway that functions in the apoptosis of unfit cells during cell competition. May be part of a NF-kappa-B and Tollo signaling cascade that regulates development of the peripheral nervous system. Possibly post-transcriptionally regulates the neuron-specific genes sc and ase, by promoting the rapid turnover of their transcripts in the wing imaginal disk.

Gene References into Functions

Early gene Broad complex(BR-C) could be regulating the immune pathways by activating Relish and physically interacting with it to activate antimicrobial peptides expression. PMID:25931442
The Toll/NF-kappaB signaling pathway is required for epidermal wound repair in Drosophila. PMID:25427801
Epistatic analysis indicates that DMAP1 acts in parallel or downstream of Relish. PMID:24947515
the IMD/Relish signaling pathway is a central regulator of microbiota-mediated transcriptional response PMID:24733183
Relish mutations inhibited upregulation of innate immune response genes and neurodegeneration in ATM mutants. PMID:23502677
induction of antimicrobial peptide expression is via activation of the NF-kappaB transcription factor Relish in the immune deficiency (Imd) pathway PMID:22470576
NF-kappaB transcription factor Relish mediates the alternative pathway of cell death in Drosophila PMID:22328149
Data show that inhibition of NF-kappaB with pyrrolidine dithiocarbamate increases the median lifespan (13-20%) and the age of 90% mortality (11-14%) in Drosophila melanogaster females and males, respectively. PMID:21483034
Ectopic Ras/MAPK pathway activation results in the suppression of Drosophila IMD/NF-kappaB signalling. PMID:21297578
immune response increases sleep in flies in a manner that is gated by the circadian clock and that requires the NFkappaB Relish; supports a role of sleep in a recovery process and demonstrate a conserved feature of the Drosophila model of sleep. PMID:20144235
activation is controlled by PGRP-LC PMID:11872802
Overexpression of a pattern-recognition receptor, peptidoglycan-recognition protein-LE, activates imd/relish-mediated antibacterial defense and the prophenoloxidase cascade in larvae. PMID:12359879
a caspase target site, located in the linker region between the Rel and the IkappaB-like domain, is the site of signal-dependent cleavage PMID:12732719
Rel synergy with GATA plays a pervasive role in the immune response. PMID:14731391
Rel limits duration of JNK activation in response to Gram-neg infections. Rel activation is linked to TAK1 degradation, terminating JNK signaling, resulting in a transient JNK-dependent response that precedes sustained induction of immune loci. PMID:15037551
Molecular modeling was used to compare the tertiary structure of Relish with two other Drosophila proteins. PMID:17785540
the C-terminal IkappaB-like domain executes a scaffolding and recruiting function for full activation of Relish. PMID:19135474
show that the IKK complex controls Relish by direct phosphorylation on serines 528 and 529. Surprisingly, these phosphorylation sites are not required for Relish cleavage, nuclear translocation, or DNA binding PMID:19497884

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Subcellular Location

[Nuclear factor NF-kappa-B p68 subunit]: Nucleus.; [Nuclear factor NF-kappa-B p110 subunit]: Cytoplasm.; [Nuclear factor NF-kappa-B p49 subunit]: Cytoplasm.

Database Links

UNIGENE: Dm.4154

KEGG: dme:Dmel_CG11992

STRING: 7227.FBpp0088375

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