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Recombinant Drosophila melanogaster Metabotropic glutamate receptor (mGluRA), partial

Recombinant Drosophila melanogaster Metabotropic glutamate receptor (mGluRA), partial

Code
MSDS	MSDS Datasheet
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Source
Conjugate
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Target Background

Product Details

Purity

>85% (SDS-PAGE)

Target Names

mGluR

Uniprot NO.

P91685

Species

Drosophila melanogaster (Fruit fly)

Source

Yeast

Protein Length

Partial

Tag Info

N-terminal His-tagged/Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.

Storage

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

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Target Background

Function(From Uniprot)

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors.

Gene References into Functions

transgenic flies expressing a number of GPCRs in the photoreceptor cells PMID:11964379
sterol-rich lipid rafts act as positive allosteric regulators of DmGluRA. PMID:12923296
Two roles were found for DmGluRA in presynaptic mechanisms: (1) modulation of presynaptic excitability properties important for control of activity-dependent neurotransmitter release and (2) modulation of synaptic architecture. PMID:15483129
Metabotropic glutamate receptor A (mGluRA) and fragile X mental retardation (Fmr) protein genetically interact in behavioral movement regulation. PMID:18280750
we report DmGluRA expression in most neuropile areas in both larvae and adults, but not in the lobes of the mushroom bodies PMID:18303583
DmGluRA mutations increase neuronal excitability by preventing PI3 kinase (PI3K) activation and consequently hyperactivating the transcription factor Foxo PMID:19043547

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Subcellular Location

Cell membrane; Multi-pass membrane protein.

Protein Families

G-protein coupled receptor 3 family

Tissue Specificity

Expressed in the neurons of the larval CNS from the beginning of the first until the third instar. Expression in the third-instar larval CNS is restricted to a discrete number of somas and projections in the brain lobes and in the ventral ganglion. In the

Database Links

UNIGENE: Dm.1789

KEGG: dme:Dmel_CG11144

STRING: 7227.FBpp0305080

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